Among the mutations in the amyloid precursor protein (APP) involved in familial Alzheimer's disease is the so-called Flemish mutation (A21G). Now a biochemical study of this mutation reveals the existence of a domain in APP that binds to an allosterica site in the γ-secretase complex and inhibits the enzymatic activity leading to the production of amyloidogenic peptide Aβ.
- Yuan Tian
- Bhramdeo Bassit
- Yue-Ming Li
