Nature Search

Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma

Immune checkpoint inhibitors have now been approved for the treatment of advanced hepatocellular carcinoma (HCC), however only a minority of patients appear to benefit. Here the authors report that RNase1 levels predict response to nivolumab (anti-PD1) in patients with HCC and that RNase 1 overexpression correlates with an immunosuppressive tumor microenvironment in HCC preclinical models.

Chunxiao Liu
Chenhao Zhou
Mien-Chie Hung
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.

Heng-Huan Lee
Ying-Nai Wang
Mien-Chie Hung
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-18
Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051

An integrated approach combining native mass spectrometry, hydrogen-deuterium exchange mass spectrometry, and molecular dynamics simulations was employed to investigate the inhibition mechanism of human HDAC8 by PCI-34051, in comparison to the pan-inhibitor SAHA.

Yuxiang Luo
Zhaoyue Yan
Huilin Li
ResearchOpen Access12 Feb 2025
Communications Biology

Volume: 8, P: 1-11
Gut microbial genetic variation modulates host lifespan, sleep, and motor performance

Ying Li
Simin Xu
Zuobin Zhu
Research07 Aug 2023
The ISME Journal

Volume: 17, P: 1733-1740
Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation

Weiye Zhao
Ying Xu
Fu-Sen Liang
ResearchOpen Access05 Aug 2021
Scientific Reports

Volume: 11, P: 1-11
FTO promotes clear cell renal cell carcinoma progression via upregulation of PDK1 through an m⁶A dependent pathway

Haixiang Shen
Yufan Ying
Liping Xie
ResearchOpen Access12 Aug 2022
Cell Death Discovery

Volume: 8, P: 1-12
SMAD3 and FTO are involved in miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer

Jiazhu Sun
Xueyou Ma
Ben Liu
ResearchOpen Access13 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-10
EGR2-mediated regulation of m⁶A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

Yufan Ying
Xueyou Ma
Liping Xie
ResearchOpen Access29 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-12
circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis

Xueyou Ma
Yufan Ying
Liping Xie
ResearchOpen Access23 Nov 2021
Cell Death Discovery

Volume: 7, P: 1-10
In situ molecular imaging of adsorbed protein films in water indicating hydrophobicity and hydrophilicity

Jiachao Yu
Yufan Zhou
Xiao-Ying Yu
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-8

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Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051

Gut microbial genetic variation modulates host lifespan, sleep, and motor performance

Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation

FTO promotes clear cell renal cell carcinoma progression via upregulation of PDK1 through an m⁶A dependent pathway

SMAD3 and FTO are involved in miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer

EGR2-mediated regulation of m⁶A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis

In situ molecular imaging of adsorbed protein films in water indicating hydrophobicity and hydrophilicity

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