Nature Search

Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming

Jeong Ho Moon
Hideshi Ishii
Masaki Mori
ResearchOpen Access15 Feb 2011
Nature Precedings

P: 1
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H⁺ channel Hv1

In the dimeric voltage-gated H⁺channel, Hv1/VSOP, the gating of each subunit is coupled, but the molecular basis of dimer formation and intersubunit coupling is unclear. This study shows that channel assembly and cooperative gating are mediated by the cytoplasmic domain.

Yuichiro Fujiwara
Tatsuki Kurokawa
Yasushi Okamura
ResearchOpen Access08 May 2012
Nature Communications

Volume: 3, P: 1-11
The DUF1669 domain of FAM83H is required for its localization to nuclear speckles

Takahisa Kuga
Minami Saraya
Nobuyuki Yamagishi
ResearchOpen Access10 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
The nature of the globular- to fibrous-actin transition

Actin exists in two forms in cells. Monomeric globular actin (G-actin) polymerizes to form filamentous actin (F-actin), which drives several processes such as cell motility. This paper presents a high resolution structure of F-actin and describes the differences between the conformations of the two forms of actin.

Toshiro Oda
Mitsusada Iwasa
Akihiro Narita
Research22 Jan 2009
Nature

Volume: 457, P: 441-445
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels

Functional and structural characterization of rhodopsin-bestrophin fusion proteins from marine algae unveils the existence of giant light-sensitive anion channels with unusual biophysical properties.

Andrey Rozenberg
Igor Kaczmarczyk
Moran Shalev-Benami
Research16 Jun 2022
Nature Structural & Molecular Biology

Volume: 29, P: 592-603
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particularly Kapβ2.

Hitoki Nanaura
Honoka Kawamukai
Eiichiro Mori
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-12
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Structural insights into the nucleotide base specificity of P2X receptors

Go Kasuya
Yuichiro Fujiwara
Osamu Nureki
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1

VCCN1 is a plant homolog of bestrophin channels and tunes photoreaction as a voltage-gated anion channel at thylakoids. Here, authors report the cryo-EM structures and functional features of apple VCCN1, with insights into its activation mechanism.

Tatsuya Hagino
Takafumi Kato
Osamu Nureki
ResearchOpen Access06 May 2022
Nature Communications

Volume: 13, P: 1-10
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Accessory pathway analysis using a multimodal deep learning model

Makoto Nishimori
Kunihiko Kiuchi
Ken-ichi Hirata
ResearchOpen Access13 Apr 2021
Scientific Reports

Volume: 11, P: 1-8
An increase in the posterior subarachnoid space accelerates the timing of syrinx resolution after foramen magnum decompression of type I Chiari malformation

Yuichiro Ohnishi
Sho Fujiwara
Haruhiko Kishima
ResearchOpen Access27 Sept 2021
Scientific Reports

Volume: 11, P: 1-6
The time course of dysphagia following traumatic cervical spinal cord injury: a prospective cohort study

Tetsuo Hayashi
Yuichi Fujiwara
Takeshi Maeda
Research28 Aug 2019
Spinal Cord

Volume: 58, P: 53-57
Structural basis for the membrane association of ankyrinG via palmitoylation

Yuichiro Fujiwara
Hiroko X. Kondo
Kengo Kinoshita
ResearchOpen Access05 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
X-ray crystal structure of voltage-gated proton channel

Structural and functional analysis reveal the resting state of the voltage-gated proton channel Hv1. Comparison with structures of voltage-sensing domains from other systems, captured in the activated state, will aid in understanding the mechanism of voltage sensing.

Kohei Takeshita
Souhei Sakata
Atsushi Nakagawa
Research02 Mar 2014
Nature Structural & Molecular Biology

Volume: 21, P: 352-357
Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis

Rie Natatsuka
Tsuyoshi Takahashi
Tetsuji Naka
ResearchOpen Access16 Jul 2015
British Journal of Cancer

Volume: 113, P: 433-442
Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism

Naoki Fujiwara
Tatsuya Haze
Michio Otsuki
Research15 Oct 2024
Hypertension Research

Volume: 48, P: 540-552
Hypertension in children and adolescents: perspectives in Japan

Takeshi Fujiwara
Hidehiro Kaneko
Yuichiro Yano
Reviews10 Sept 2024
Hypertension Research

Volume: 47, P: 3372-3379
Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

Akira Nakamizo
Yuichiro Miyamatsu
Koji Yoshimoto
ResearchOpen Access29 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Hiroyuki Muranushi
Takero Shindo
Koji Kato
Research14 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 155-166
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts

Takehiko Oami
Satoshi Karasawa
Yasuaki Mizushima
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-7
Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

Akira Komori
Toshikazu Abe
Yasuaki Mizushima
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Crystal structures of the TRIC trimeric intracellular cation channel orthologues

Go Kasuya
Masahiro Hiraizumi
Osamu Nureki
ResearchOpen Access02 Dec 2016
Cell Research

Volume: 26, P: 1288-1301
Correction: GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Hiroyuki Muranushi
Takero Shindo
Koji Kato
Amendments and Corrections25 Aug 2020
Bone Marrow Transplantation

Volume: 56, P: 298

Search

Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H⁺ channel Hv1

The DUF1669 domain of FAM83H is required for its localization to nuclear speckles

Blood DNA virome associates with autoimmune diseases and COVID-19

The nature of the globular- to fibrous-actin transition

Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

Mapping the human genetic architecture of COVID-19

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Structural insights into the nucleotide base specificity of P2X receptors

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1

A second update on mapping the human genetic architecture of COVID-19

Accessory pathway analysis using a multimodal deep learning model

An increase in the posterior subarachnoid space accelerates the timing of syrinx resolution after foramen magnum decompression of type I Chiari malformation

The time course of dysphagia following traumatic cervical spinal cord injury: a prospective cohort study

Structural basis for the membrane association of ankyrinG via palmitoylation

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

X-ray crystal structure of voltage-gated proton channel

Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis

Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism

Hypertension in children and adolescents: perspectives in Japan

Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts

Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Crystal structures of the TRIC trimeric intracellular cation channel orthologues

Correction: GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

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