Deuterated amines play a crucial role as building blocks in drug synthesis and in identifying metabolites of novel pharmaceuticals. This study introduces a dual-functional phosphorus-doped iron single-atom catalyst that efficiently enables both reductive amination and deuteration in a one-pot process, utilizing H2 as the reducing agent and cost-effective D2O as the deuterium source.
- Haifeng Qi
- Yueyue Jiao
- Matthias Beller
