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Showing 1–50 of 57 results

Advanced filters: Author: Yukiko Kimura Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin

Here the authors reveal that oncoprotein DEK binds the nucleosome, colocalizes with H3 K27 trimethylation and stimulates Polycomb repressive complex 2 methyltransferase through chromatin compaction, as revealed by the cryo-electron microscopy structures of nucleosome-bound DEK.

Tomoya Kujirai
Kenta Echigoya
Hitoshi Kurumizaka
ResearchOpen Access21 Feb 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1183-1192
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Self-Assembly of Stereocomplex-Type Poly(lactic acid)

Yukiko Furuhashi
Yoshiharu Kimura
Naoko Yoshie
Reviews15 Sept 2006
Polymer Journal

Volume: 38, P: 1061-1067
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
New Eremophilane Sesquiterpenoid Compounds, Eremoxylarins A and B Directly Inhibit Calcineurin in a Manner Independent of Immunophilin

Yukiko Ogasawara
Jun Yoshida
Ken-ichi Kimura
Research01 Aug 2008
The Journal of Antibiotics

Volume: 61, P: 496-502
Prognostic impact of chromosomal changes at relapse after allogeneic hematopoietic cell transplantation for acute myeloid leukemia or myelodysplastic syndrome

Yosuke Okada
Hideki Nakasone
Yoshinobu Kanda
Research21 Mar 2022
Bone Marrow Transplantation

Volume: 57, P: 810-816
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
The effects of voltage dependence and ion-binding reaction rates on a thermodynamically constrained mathematical model of the Na/Ca exchanger

Shaocong Ou
Zhongyang Xiao
Akira Amano
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-20
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain

Viral vectors with intense and long-lasting transgene expression are essential for manipulating and imaging of neuronal activity in the primate brain. Here, the authors created a mosaic vector composed of capsid proteins derived from AAV1 and AAV2 that exhibits improved transgene expression and neuronal specificity.

Kei Kimura
Yuji Nagai
Masahiko Takada
ResearchOpen Access08 Aug 2023
Nature Communications

Volume: 14, P: 1-17
TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding

The authors show that shortening of the basal process in neural progenitor cells by depletion of TAG-1 results in overcrowding in the periventricular space and, eventually, delamination and aberrant migration. These results suggest that one of the functions of interkinetic nuclear migration is to prevent progenitor congestion and mechanical stress.

Mayumi Okamoto
Takashi Namba
Takaki Miyata
Research22 Sept 2013
Nature Neuroscience

Volume: 16, P: 1556-1566
ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viability

Tomomi Taguchi
Kaori Kimura
Takeshi Miyatsuka
ResearchOpen Access07 Jun 2023
Scientific Reports

Volume: 13, P: 1-10
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

Polyamines produced by intestinal bacteria are thought to have beneficial effects on the host. Here the authors show that these polyamines increase regulatory macrophage abundance and are taken up by colonic epithelial cells to enhance colonic barrier function and immunity in mice.

Atsuo Nakamura
Shin Kurihara
Koji Hase
ResearchOpen Access08 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Regulation of locomotor speed and selection of active sets of neurons by V1 neurons

During evoked swims, zebrafish larvae transition from fast to slow speeds. Here, the authors elucidate the circuit mechanisms in the central pattern generators in the spinal cord and show that genetically labeled V1 spinal interneurons provide in phase inhibition onto fast and slow motor neurons that are involved in the switching behaviour.

Yukiko Kimura
Shin-ichi Higashijima
ResearchOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1-12
Interstitial lung disease with anti-melanoma differentiation-associated gene 5 antibody after allogeneic hematopoietic stem cell transplantation

Masaharu Tamaki
Shimpei Matsumi
Yoshinobu Kanda
Research04 Jun 2022
Bone Marrow Transplantation

Volume: 57, P: 1382-1388
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.

Yuji Nagai
Erika Kikuchi
Takafumi Minamimoto
ResearchOpen Access06 Dec 2016
Nature Communications

Volume: 7, P: 1-8
Guanine crystals regulated by chitin-based honeycomb frameworks for tunable structural colors of sapphirinid copepod, Sapphirina nigromaculata

Tsubasa Kimura
Mihiro Takasaki
Hiroaki Imai
ResearchOpen Access10 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
In vitro synthesis of linear α-1,3-glucan and chemical modification to ester derivatives exhibiting outstanding thermal properties

Sakarin Puanglek
Satoshi Kimura
Tadahisa Iwata
ResearchOpen Access29 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
Treatment of chronic pain in pediatric rheumatic disease

No detailed guidelines exist for treating pain in children with rheumatic diseases. In this Review, the authors discuss the multifactorial nature of pain in these children and advise that pain treatment should be interdisciplinary and consist of nonpharmacologic as well as pharmacologic interventions.

Yukiko Kimura
Gary A Walco
Reviews01 Apr 2007
Nature Clinical Practice Rheumatology

Volume: 3, P: 210-218
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Identification of H₂S₃ and H₂S produced by 3-mercaptopyruvate sulfurtransferase in the brain

Yuka Kimura
Yukiko Toyofuku
Hideo Kimura
ResearchOpen Access06 Oct 2015
Scientific Reports

Volume: 5, P: 1-11
Human protein factory for converting the transcriptome into an in vitro–expressed proteome

A collection of 33,275 human Gateway entry clones and complementary in vitro protein expression methodologies are described that allow proteome-scale production of human proteins. This 'human protein factory' was validated by expression of 13,364 human proteins and assessment of activity in a variety of assays.

Naoki Goshima
Yoshifumi Kawamura
Nobuo Nomura
Research23 Nov 2008
Nature Methods

Volume: 5, P: 1011-1017
Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment

Koichi Yamamoto
Hiroshi Akasaka
Hiromi Rakugi
Research24 Feb 2022
Hypertension Research

Volume: 45, P: 612-619
Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish

Kohei Kawano
Kagayaki Kato
Shin-ichi Higashijima
ResearchOpen Access14 Mar 2022
Scientific Reports

Volume: 12, P: 1-12
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Physcomitrella STEMIN transcription factor induces stem cell formation with epigenetic reprogramming

In moss, a subgroup of uncharacterized AP2/ERF transcription factors called STEMIN promotes stem cell formation and regeneration, specifically through a repressive chromatin mark on its target genes.

Masaki Ishikawa
Mio Morishita
Mitsuyasu Hasebe
Research08 Jul 2019
Nature Plants

Volume: 5, P: 681-690
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Features of repertoire diversity and gene expression in human cytotoxic T cells following allogeneic hematopoietic cell transplantation

Cytomegalovirus reactivation is an important concern after allogeneic stem cell transplantation (allo-HCT) or organ transplantation. Here, Hideki Nakasone et al. investigate changes in repertoire diversity and gene expression among clinically-transferred T cells to improve our understanding of immune reconstitution following allo-HCT.

Hideki Nakasone
Machiko Kusuda
Yoshinobu Kanda
ResearchOpen Access11 Oct 2021
Communications Biology

Volume: 4, P: 1-18
Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps

Takahiro Ninomiya
Emiko Noguchi
Shigeharu Fujieda
ResearchOpen Access30 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2

Kenichi Todo
Shinichi Yoshimura
Naoyuki Uchiyama
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
Novel USP9X variants in two patients with X-linked intellectual disability

Yoshinori Tsurusaki
Yukiko Kuroda
Kenji Kurosawa
ResearchOpen Access21 Oct 2019
Human Genome Variation

Volume: 6, P: 1-3
Discordant phenotype caused by CASK mutation in siblings with NF1

Hiroaki Murakami
Yuichi Kimura
Kenji Kurosawa
ResearchOpen Access26 Apr 2019
Human Genome Variation

Volume: 6, P: 1-4
Augmentation of Intrarenal Angiotensin II Levels in Uninephrectomized Aldosterone/Salt-Treated Hypertensive Rats; Renoprotective Effects of an Ultrahigh Dose of Olmesartan

Yu-Yan Fan
Ryoko Baba
Akira Nishiyama
Research01 Mar 2006
Hypertension Research

Volume: 29, P: 169-178
Recurrent occurrences of CDKL5 mutations in patients with epileptic encephalopathy

Toshiyuki Yamamoto
Keiko Shimojima
Katsumi Imai
ResearchOpen Access05 Nov 2015
Human Genome Variation

Volume: 2, P: 1-4
Increased CD83 expression of CD34-positive monocytes in donors during peripheral blood stem cell mobilization in humans

Hideki Nakasone
Misato Kikuchi
Yoshinobu Kanda
ResearchOpen Access11 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

Hirohiko Kohjitani
Shigeya Koda
Takeshi Kimura
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-16
Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes

The physiological role of Vsp in zebrafish is assessed, revealing Vsp expression in the mid-intestine for dietary protein absorption. A comparative study on marine invertebrate Ciona intestinalis suggests conservation of Vsp function in the GI tract.

Adisorn Ratanayotha
Makoto Matsuda
Yasushi Okamura
ResearchOpen Access10 Sept 2022
Communications Biology

Volume: 5, P: 1-15
Development of a time-series shotgun metagenomics database for monitoring microbial communities at the Pacific coast of Japan

Kazutoshi Yoshitake
Gaku Kimura
Takashi Gojobori
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-13
Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma

Makoto Nakagawa
Fumihiko Nakatani
Issay Kitabayashi
ResearchOpen Access12 Aug 2019
Oncogene

Volume: 38, P: 6835-6849
Associations between febrile neutropenia-related parameters and the risk of acute GVHD or non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Kazuaki Kameda
Shun-ichi Kimura
Yoshinobu Kanda
Research31 Aug 2018
Bone Marrow Transplantation

Volume: 54, P: 707-716
Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering

Yukiko Kimura
Yu Hisano
Shin-ichi Higashijima
ResearchOpen Access08 Oct 2014
Scientific Reports

Volume: 4, P: 1-7

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