Nature Search

Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy

Chronic UV exposure has been associated with immune system suppression. Here the authors show that enhanced tumor growth and resistance to PD1 blockade in mice exposed to UV irradiation is associated with induced expression of Ly6a in CD8 + T cells and that targeting Ly6a enhances anti-tumor immune responses in models resistant to anti-PD1.

Avishai Maliah
Nadine Santana-Magal
Carmit Levy
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Author Correction: Surface properties of SAR11 bacteria facilitate grazing avoidance

Ayelet Dadon-Pilosof
Keats R. Conley
Gitai Yahel
Amendments and Corrections20 Oct 2017
Nature Microbiology

Volume: 2, P: 1696
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Chronic antiretroviral therapy does not eradicate HIV infection. Here, the authors describe a potentially one-shot alternative by engineering B cells to express anti-HIV antibodies and undergo memory retention, isotype switching and clonal expansion

Alessio D. Nahmad
Yuval Raviv
Adi Barzel
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Loss of lamin A function increases chromatin dynamics in the nuclear interior

Nuclear lamins mediate interactions between chromatin and the nuclear envelope, however they are also found throughout the nucleoplasm. By measuring the dynamics of different genomic loci, Bronshtein et al.show that lamin A is also required for the stability of the nuclear interior.

I. Bronshtein
E. Kepten
Y. Garini
ResearchOpen Access24 Aug 2015
Nature Communications

Volume: 6, P: 1-9
Single-allele analysis of transcription kinetics in living mammalian cells

Single integration of a target gene expressing MS2-binding stem loops allows the real time quantification of transcriptional bursts, promoter firings and cell cycle–dependent transcription rates.

Sharon Yunger
Liat Rosenfeld
Yaron Shav-Tal
Research18 Jul 2010
Nature Methods

Volume: 7, P: 631-633
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

B cells are engineered in vivo to secrete anti-HIV antibodies

Alessio D. Nahmad
Cicera R. Lazzarotto
Adi Barzel
Research09 Jun 2022
Nature Biotechnology

Volume: 40, P: 1241-1249
Ethnicity has a multiplex impact upon the risk of a full mutation expansion among female heterozygotes for FMR1 premutation

Noam Domniz
Liat Ries Levavi
Shay Ben-Shachar
Research20 Jan 2021
Genetics in Medicine

Volume: 23, P: 1023-1027
Evaluation of the digital genetic assistant in technology assisted genetic counseling for genetic carrier screening

Yuval Yaron
Vered Ofen Glassner
Hagit Baris Feldman
ResearchOpen Access29 Mar 2025
npj Digital Medicine

Volume: 8, P: 1-8
Whole-exome sequencing in fetuses with central nervous system abnormalities

Adi Reches
Liran Hiersch
Yuval Yaron
Research14 Aug 2018
Journal of Perinatology

Volume: 38, P: 1301-1308
Brachydactyly A-1 mutations restricted to the central region of the N-terminal active fragment of Indian Hedgehog

Ashley M Byrnes
Lemuel Racacho
Dennis E Bulman
Research11 Mar 2009
European Journal of Human Genetics

Volume: 17, P: 1112-1120
Large-scale population screening for spinal muscular atrophy: Clinical implications

Shay Ben-Shachar
Avi Orr-Urtreger
Yuval Yaron
Research11 Jan 2011
Genetics in Medicine

Volume: 13, P: 110-114
Dynamic modification strategy of the Israeli carrier screening protocol: inclusion of the Oriental Jewish Group to the cystic fibrosis panel

Orit Reish
Zvi U Borochowitz
Daphne Chapman-Shimshoni
Research01 Feb 2009
Genetics in Medicine

Volume: 11, P: 101-103
Protein kinase C epsilon activation improves early survival in an acute porcine model of controlled hemorrhage

Maya Simchoni
Linn Wagnert-Avraham
Ariel Furer
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Chronic expression of p16^INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

It is unclear how resident p16-expressing senescent cells affect the propensity of tissues to develop cancer. Here, the authors show that chronic p16 expression in the mouse epidermis causes hyperplasia and dysplasia through Wnt-mediated paracrine stimulation of proliferating keratinocytes, and can contribute to tumour formation.

Narmen Azazmeh
Benjamin Assouline
Ittai Ben-Porath
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-13
Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes

Joseph Gleeson and colleagues report that mutations in TMEM216 cause Joubert, Meckel and related syndromes. They further show that TMEM216 localizes to the base of cilia and that its loss leads to defects in ciliogenesis and centrosome docking.

Enza Maria Valente
Clare V Logan
Joseph G Gleeson
Research30 May 2010
Nature Genetics

Volume: 42, P: 619-625
Surface properties of SAR11 bacteria facilitate grazing avoidance

In situ sampling reveals that members of the SAR11 clade show significantly lower retention by mucous filter feeders, and that this is probably due to their reduced hydrophobic cell surface, suggesting that cell surface properties are important factors in predator–prey interactions.

Ayelet Dadon-Pilosof
Keats R. Conley
Gitai Yahel
Research02 Oct 2017
Nature Microbiology

Volume: 2, P: 1608-1615
Ethnic effect on FMR1 carrier rate and AGG repeat interruptions among Ashkenazi women

Karin Weiss
Avi Orr-Urtreger
Shay Ben-Shachar
Research29 May 2014
Genetics in Medicine

Volume: 16, P: 940-944
Carrier testing for spinal muscular atrophy

Jonathan M Gitlin
Kenneth Fischbeck
R Rodney Howell
Research30 Aug 2010
Genetics in Medicine

Volume: 12, P: 621-622
Quantifying the transcriptional output of single alleles in single living mammalian cells

Sharon Yunger
Liat Rosenfeld
Yaron Shav-Tal
Protocols31 Jan 2013
Nature Protocols

Volume: 8, P: 393-408
Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

Yaron Meirow
Milena Jovanovic
Michal Baniyash
ResearchOpen Access08 Apr 2022
Bone Research

Volume: 10, P: 1-17

Search

Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy

Author Correction: Surface properties of SAR11 bacteria facilitate grazing avoidance

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Loss of lamin A function increases chromatin dynamics in the nuclear interior

Single-allele analysis of transcription kinetics in living mammalian cells

In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

Ethnicity has a multiplex impact upon the risk of a full mutation expansion among female heterozygotes for FMR1 premutation

Evaluation of the digital genetic assistant in technology assisted genetic counseling for genetic carrier screening

Whole-exome sequencing in fetuses with central nervous system abnormalities

Brachydactyly A-1 mutations restricted to the central region of the N-terminal active fragment of Indian Hedgehog

Large-scale population screening for spinal muscular atrophy: Clinical implications

Dynamic modification strategy of the Israeli carrier screening protocol: inclusion of the Oriental Jewish Group to the cystic fibrosis panel

Protein kinase C epsilon activation improves early survival in an acute porcine model of controlled hemorrhage

Chronic expression of p16^INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes

Surface properties of SAR11 bacteria facilitate grazing avoidance

Ethnic effect on FMR1 carrier rate and AGG repeat interruptions among Ashkenazi women

Carrier testing for spinal muscular atrophy

Quantifying the transcriptional output of single alleles in single living mammalian cells

Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

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