Nature Search

The efficacy and safety of inhaled peptide YKYY017 for COVID-19 patients with mild illness: a phase 2 randomized controlled trial

In this phase 2 trial, YKYY017, a SARS-CoV-2 membrane fusion inhibitor, was tested against mild to moderate COVID-19. Inhaled YKYY017 at 20 mg produced a numerically higher viral load reduction compared with placebo on Day 4, suggesting potential antiviral activity. Both inhaled 10 mg and 20 mg YKYY017 were well-tolerated and had acceptable safety profiles.

Yeming Wang
Lianhan Shang
Bin Cao
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-9
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma

Qiong Mei
Yu Zhang
Yuxian Shen
ResearchOpen Access19 Feb 2025
Cell Death & Differentiation

Volume: 32, P: 1441-1459
Author Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Mengyun Zhang
Yong Dong
Jinyong Wang
Amendments and Corrections02 Jun 2025
Nature Immunology

Volume: 26, P: 975
Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures

Fibers derived from non-silk proteins hold potential for various biomedical applications, but mechanically-balanced and highly-biocompatible regenerated protein fibers are elusive. Here, the authors report an entanglement-reinforced strategy to fabricate keratin/albumin bio-fibers that show high strength and toughness, along with favorable biocompatibility, degradability and immunocompatibility.

Haonan He
Xianchi Zhou
Jian Ji
ResearchOpen Access27 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Tailored ozone activation on geometrical-site-dependent cobalt with selective coordination

Geometrical-site-dependent catalytic ozone activation is demonstrated on the Co²⁺_Td and Co³⁺_Oh sites in spinel oxides, where the spin-polarized Co²⁺_Td outperforms Co³⁺_Oh site in •OH generation, achieving a 17.6-fold increase in turnover frequency.

Shenning Liu
Yuxian Wang
Shaobin Wang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection

Yitian Xu
Ying Zheng
Bin Cao
ResearchOpen Access23 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-13
PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Xinyu Wang
Yuhua Xue
Dan Yu
ResearchOpen Access15 May 2025
Nature Communications

Volume: 16, P: 1-18
Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Mengyun Zhang
Yong Dong
Jinyong Wang
Amendments and Corrections18 Jun 2018
Nature Immunology

Volume: 19, P: 1036
Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution

Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, genome rearrangement, gene evolution and cotton fiber biology.

Fuguang Li
Guangyi Fan
Shuxun Yu
ResearchOpen Access20 Apr 2015
Nature Biotechnology

Volume: 33, P: 524-530
Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi

Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.

Min He
Jia Su
Xuewei Chen
Research21 Sept 2020
Nature Microbiology

Volume: 5, P: 1565-1575
A tripartite rheostat controls self-regulated host plant resistance to insects

Insect salivary protein (BISP) targets OsRLCK185 to suppress defence in susceptible plants, whereas in resistant plants BISP binds BPH14 to activate host plant resistance. To restore cellular homeostasis, the resistance mechanism is fine-tuned by selective autophagy.

Jianping Guo
Huiying Wang
Guangcun He
ResearchOpen Access14 Jun 2023
Nature

Volume: 618, P: 799-807
Mechanical properties and sealing performance evaluation of packers in high temperature underground gas storage

Yuxian He
Haiyun Ma
Xianzhong Yi
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

Lung injury initiates a series of wound-healing responses, which if unregulated, can lead to fibrosis. Liet al. show that the deubquitinase CYLD has a key role in the prevention of fibrosis by inhibiting transforming growth factor β-signalling through the direct deubiquitination of the protein kinase Akt.

Jae Hyang Lim
Hirofumi Jono
Jian-Dong Li
ResearchOpen Access10 Apr 2012
Nature Communications

Volume: 3, P: 1-12
Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Wang and colleagues show that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is absent from committed B cells and T cells, can reprogram pro-pre-B cells into functional early T cell lineage progenitors.

Mengyun Zhang
Yong Dong
Jinyong Wang
Research12 Feb 2018
Nature Immunology

Volume: 19, P: 279-290
Establishment and application of the environment evaluation model for beneficiation plant

Houdong Liu
Qian Kang
Songtao Yu
ResearchOpen Access18 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
Design and mechanical properties analysis of drill pipe’s joint thread with unequal taper under complex loads

Hangming Liu
Yongpeng Song
Song Hou
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-18
First-line treatment of anti-EGFR monoclonal antibody cetuximab β plus FOLFIRI versus FOLFIRI alone in Chinese patients with RAS/BRAF wild-type metastatic colorectal cancer: a randomized, phase 3 trial

Yuankai Shi
Yi Ba
Sheng Hou
ResearchOpen Access07 May 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-9
Ultimate load analysis of casings in slip-working sections of underground gas storage wells

Yuxian He
Haiyun Ma
Xianzhong Yi
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-21
The spike protein of SARS-CoV — a target for vaccine and therapeutic development

The outbreaks of severe acute respiratory syndrome (SARS) between 2002 and 2004 killed hundreds of people. Vaccines against the SARS coronavirus (SARS-CoV) could protect the population during future outbreaks. In this Review, Shibo Jiang and colleagues describe such vaccines, as well as other therapeutics, based on the SARS-CoV spike protein.

Lanying Du
Yuxian He
Shibo Jiang
Reviews09 Feb 2009
Nature Reviews Microbiology

Volume: 7, P: 226-236
Resequencing of 243 diploid cotton accessions based on an updated A genome identifies the genetic basis of key agronomic traits

The authors report an improved genome assembly of G. arboretum and resequencing of 243 diploid cotton accessions. GWAS and QTL-seq identify a number of candidate loci that associate with seed oil content, disease resistance and yield traits in cotton.

Xiongming Du
Gai Huang
Fuguang Li
Research07 May 2018
Nature Genetics

Volume: 50, P: 796-802
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Dongfeng Gu and colleagues report a genome-wide association study for coronary artery disease in Han Chinese individuals. They identify four loci newly associated with coronary artery disease.

Xiangfeng Lu
Laiyuan Wang
Dongfeng Gu
Research01 Jul 2012
Nature Genetics

Volume: 44, P: 890-894
Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer

Miao-Zhen Qiu
Yuxian Bai
Hui-Yan Luo
ResearchOpen Access16 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome

Shurui Bu
Yuxian Wang
Jianming Zhi
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-9
Role of agonistic autoantibodies against type-1 angiotensin II receptor in the pathogenesis of retinopathy in preeclampsia

Fang Liu
Yuxian Wang
Jianming Zhi
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses

Yuanmei Zhu
Danwei Yu
Yuxian He
ResearchOpen Access03 Aug 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3
MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling

Yanyan Liang
Qiong Mei
Yuxian Shen
ResearchOpen Access18 Sept 2024
Cell Death & Disease

Volume: 15, P: 1-15
IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma

Mengxiang Zhao
Yijia He
Liang Ding
Research03 Dec 2022
British Journal of Cancer

Volume: 128, P: 833-843
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

Lijian Chen
Lijie Feng
Yuxian Shen
ResearchOpen Access02 Feb 2015
Scientific Reports

Volume: 5, P: 1-13
Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8⁺ T cell responses in HLA-A transgenic mice

Xiaoxiao Jin
Yan Ding
Guangyu Zhao
ResearchOpen Access02 Nov 2021
Cellular & Molecular Immunology

Volume: 18, P: 2588-2608
Generation of HIV-resistant cells with a single-domain antibody: implications for HIV-1 gene therapy

Hongliang Jin
Xiaoran Tang
Yuxian He
ResearchOpen Access18 Jan 2021
Cellular & Molecular Immunology

Volume: 18, P: 660-674
Chromosome-scale genomes of commercially important mahoganies, Swietenia macrophylla and Khaya senegalensis

Sunil Kumar Sahu
Min Liu
Chengzhong He
ResearchOpen Access25 Nov 2023
Scientific Data

Volume: 10, P: 1-9
Cell membrane anchoring strategies for HIV gene therapy

Yani Gong
Yuxian He
Comments & Opinion27 Mar 2023
Cellular & Molecular Immunology

Volume: 20, P: 683-685
Chromosome-scale genomes of commercial timber trees (Ochroma pyramidale, Mesua ferrea, and Tectona grandis)

Sunil Kumar Sahu
Min Liu
Huan Liu
ResearchOpen Access03 Aug 2023
Scientific Data

Volume: 10, P: 1-13

Search

The efficacy and safety of inhaled peptide YKYY017 for COVID-19 patients with mild illness: a phase 2 randomized controlled trial

Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma

Author Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures

Tailored ozone activation on geometrical-site-dependent cobalt with selective coordination

Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection

PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution

Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi

A tripartite rheostat controls self-regulated host plant resistance to insects

Mechanical properties and sealing performance evaluation of packers in high temperature underground gas storage

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Establishment and application of the environment evaluation model for beneficiation plant

Design and mechanical properties analysis of drill pipe’s joint thread with unequal taper under complex loads

First-line treatment of anti-EGFR monoclonal antibody cetuximab β plus FOLFIRI versus FOLFIRI alone in Chinese patients with RAS/BRAF wild-type metastatic colorectal cancer: a randomized, phase 3 trial

Ultimate load analysis of casings in slip-working sections of underground gas storage wells

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

Resequencing of 243 diploid cotton accessions based on an updated A genome identifies the genetic basis of key agronomic traits

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer

Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome

Role of agonistic autoantibodies against type-1 angiotensin II receptor in the pathogenesis of retinopathy in preeclampsia

SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses

MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling

IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8⁺ T cell responses in HLA-A transgenic mice

Generation of HIV-resistant cells with a single-domain antibody: implications for HIV-1 gene therapy

Chromosome-scale genomes of commercially important mahoganies, Swietenia macrophylla and Khaya senegalensis

Cell membrane anchoring strategies for HIV gene therapy

Chromosome-scale genomes of commercial timber trees (Ochroma pyramidale, Mesua ferrea, and Tectona grandis)

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