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Here, the authors fabricate printed Ag/MoS₂/Ag heterostructures that can be used as zero-static power switches. When combined with a printed graphene metasurface, the platform enables reconfigurable electromagnetic wave manipulation and control.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Treatment of supported ceria nanoparticles at high temperature in gasoline vehicle exhaust/steam results in their dispersion into atomically thin oxide domains with enhanced oxygen mobility and storage capacity.

Leishmania donovani is a protozoan parasite that can cause fatal infections in humans. Here the authors present a high resolution cryoEM structure of the L. donovani80S ribosome and compare it to its human counterpart to provide insight into the basis for drug selectivity towards this eukaryotic parasite.

The structures of the biotin-dependent carboxylases have revealed details of their function. Here, the authors describe the first structure of Pseudomonasgeranyl-CoA carboxylase, and compare it with the previously characterised homologous 3-methylcrotonyl-CoA carboxylase.

For almost forty years, N-(1-pyrene) iodoacetamide has been used to label actin at C374, but the mechanisms of the fluorescence changes are still unknown due to the lack of structural information. Here authors provide cryo-EM structures of actin filaments with N-1-pyrene conjugated to cysteine 374 and either ADP or ADP-phosphate in the active site.

Methanosuratincola petrocarbonis LWZ-6 is a strict hydrogen-dependent methylotrophic methanogen that does not ferment sugars, peptides or amino acids.

Strong oxygen octahedral coupling is found to transfer the octahedral rotation between NdGaO₃ and La_2/3Sr_1/3MnO₃, allowing manipulation of the heterostructures’ magnetic and electronic anisotropic properties by engineering the oxygen network.

The bacterial type III secretion system of Gram-negative bacteria uses its core, the needle complex, to penetrate through the infected host cell membrane. Here authors show a near-atomic resolution structure of a needle complex which sheds light on the assembly and function of this nanomachine.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Mechanical twinning is difficult to trigger in face centered cubic alloys with high stacking fault energies (SFEs) under standard tensile loading. Here, the authors report high stress twinning in a bulk compositionally complex steel of very high SFE, enhancing the material’s mechanical performance.

Using a sol–gel process, monoliths of metal–organic frameworks were fabricated. With an enhanced methane volumetric uptake of 259 cm³ (STP) cm⁻³, and robust mechanical properties, this meets technological targets.

Self-assembled perovskite nanoplatelets emit linearly polarized light, enabling the realization of red perovskite light-emitting diodes with a 74.4% degree of linear polarization.

Cryo-EM structures of the pre- and postcontraction states of Pseudomonas aeruginosa R-type pyocins provide details of the conformational changes between the tube and sheath that take place during contraction.

Reduced-dimensional halide perovskites are promising for light-emitting diodes but suffer from photo-degradation. Here Quan et al. identify the edge of the perovskite nanoplatelets as the degradation channels and use phosphine oxides to passivate the edges and boost device performance and lifetime.

Cryo-EM, X-ray crystallography and mutational analyses reveal how Dengue and Zika virus protein NS5 suppresses STAT2 activity and interferon response in host cells.

The safety and efficacy of ribonucleoproteins for genome editing can be enhanced by formulations of lipid nanoparticles optimized for enhanced stability, delivery efficiency and editing potency of the protein complexes.

Glass-to-glass transitions can help understanding the glass nature, but it remains difficult to tune metallic glasses into significantly different glass states. Here the authors demonstrate the high-entropy effects in glass-to-glass transitions of high-entropy metallic glasses.

The streptococcal M1 protein can cause vascular leakage and tissue injury and these pathologies are dependent on its interaction with host fibrinogen and subsequent activation of neutrophils. This study presents the structural basis for this process.

Near-atomic resolution structure of bluetongue virus non-structural protein 1 (NS1) provides insights into its dynamic tubular assemblies and their contribution to NS1 function in viral protein synthesis.

Sensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of single nucleotides.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Bioresorbable electronic stimulators can deliver electrical stimulation in rodents to enhance functional muscle recovery after nerve injury. Here, the authors present a bioresorbable dynamic covalent polymer that enables reliable, long-lived operation of soft, stretchable devices of this type.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

This study reveals features of Epstein–Barr virus that are similar but not identical to the closely related Kaposi’s sarcoma-associated herpesvirus. The authors provide locations of protein components within the viral capsid and reveal different conformers of protein components by revealing variations in links between capsid proteins and exploiting approaches with relaxation of symmetry. The capsid-associated tegument complex is loaded on to the capsid with long-range asymmetry, relative to the location of the portal vertex (the site of genome entry and egress).

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

3D heterostructures offer properties that are inaccessible in bulk single-phase solids, but synthetic approaches are limited. The authors use mechanochemical reshuffling of binary precursors and subsequent annealing to design structurally aligned misfit heterostructures with well-defined atomic arrangements.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Multi-modal analysis is used to generate a 3D atlas of the upper limb area of the mouse primary motor cortex, providing a framework for future studies of motor control circuitry.

In absence of dangling bonds, van der Waals layered crystals are expected to have inert surfaces. In contrast, here the authors show presence of surface electron accumulation in MoS₂, with a surface electron concentration nearly four orders of magnitude higher than that of MoS₂ inner bulk.

Gas-evolving catalysts suffer from severe mass transport limitations under industrial conditions. Here, the authors report an interfacial metal-layer engineering strategy to separate bubble nucleation from active sites, enabling transfer-resistance-free electrocatalytic interfaces.

High-density, intrinsically stretchable transistors with high driving ability and integrated circuits with high operation speed and large-scale integration were enabled by a combination of innovations in materials, fabrication process design, device engineering and circuit design.

Graphene/hBN moiré superlattices exhibit a new set of Dirac mini-bands, whose interband transitions—together with free electrons in the ordinary Dirac bands—modify the nature of the plasmons, as revealed by infrared near-field microscopy.

Magnetotransport signature of topological semimetal states has been observed but restricted at very low temperature. Here, Zhanget al. report magnetic field-modulated chiral charge pumping and valley diffusion in Cd₃As₂up to room temperature.

Experiments demonstrate a class of van der Waals nanowires, made from layered crystals of the semiconductor germanium sulfide, in which a tunable interlayer twist evolves naturally during synthesis.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The product selectivity of photocatalytic carbon dioxide reduction from carbon monoxide to methane is determined by the active center from metal to sulfur site in metal sulfides. Non-metal sulfur in CuInSnS4 octahedral nanocrystal acts as carbon dioxide activation center for switching selectivity to methane.

Machine-learning algorithms are used to generate single-particle three-dimensional reconstructions, revealing that highly symmetrical dodecahedral silica cages, around 10 nm in size, self-assemble in the presence of surfactant micelles.

Using cryo-electron tomography to detect individual GABA_A receptors in hippocampal synapses, we discovered a hierarchical and mesophasic organization of inhibitory postsynaptic density proteins that enables efficient synaptic transmission.

While metal–organic frameworks exhibit record-breaking gas storage capacities, their typically powdered form hinders their industrial applicability. Here, the authors engineer UiO-66 into centimetre-sized monoliths with optimal pore-size distributions, achieving benchmark volumetric working capacities for both CH₄ and CO₂.

Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associated tegument protein complexes.