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The prevalence of N⁶-adenine DNA methylation in mammals was previously unknown; this study reveals that N⁶-methyladenine can be found in mouse embryonic stem cells, especially at subfamilies of young (<1.5 million years old) LINE-1 transposons.

Cotton fibre is the most important renewable material for textiles, with a huge economic output. Here the authors show that a homeodomain-leucine zipper transcription factor, GhHOX3, transduces a gibberellin signal that in turn promotes fibre cell elongation.

RNA polymerase V transcription in plants, which is needed DNA methylation and transcriptional silencing, requires components of the DDR complex. Here the authors show that all components of the DDR complex co-localize with Pol V and report the cryoEM structures of two complexes associated with Pol V recruitment.

NanoLuc substrates with improved solubility and bioavailability, hydrofurimazine and fluorofurimazine, strongly enhance bioluminescence signals in vivo and enable bright dual-color bioluminescent imaging with AkaLuc and AkaLumine.

Cryo-EM, X-ray crystallography and mutational analyses reveal how Dengue and Zika virus protein NS5 suppresses STAT2 activity and interferon response in host cells.

Metallic resistance of two-dimensional electron gases normally increases with temperature increasing. Here, the authors find a resistance decrease with increasing temperature at very low temperatures in two-dimensional electron metal described by Fermi liquid theory.

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.

Finding new drug targets may open up a way to combat microbial infections. In this work, authors present the molecular basis for the dual-function regulator MexL as a target to control the virulence and pathogenesis of opportunistic pathogen Pseudomonas aeruginosa.

Channelrhodopsins are light-gated ion channels for optogenetics. Here, authors report the 2.7 Å cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens, revealing a 6-s-cis retinal configuration and unique C-terminal modulation.

A new type of fermion, corresponding to a three-fold degeneracy in the electronic band structure of crystalline molybdenum phosphide, is observed, which lies conceptually between Dirac and Weyl fermions.

Nie et al. describe a mechanism underlying the degradation of the histone methyltransferase NSD2 through the recruitment of FBXO22 E3 ligase, providing a chemical probe for NSD2 function study and targeted protein degradation.

Triclosan (TCS), an antimicrobial agent commonly found in consumer products, has been reported to exacerbates colitis in animal models. Here, using in vitro and in vivo approaches, the authors show that gut bacterial enzymes can drive the metabolic activation and gut toxicity of TCS, highlighting an important role of intestinal microbial factors in the complex etiology of colitis.

Whether antigen processing and presentation differs between pathogen-derived antigens and self-antigens is not clear. Here the authors use a reductionist cell-free approach to study antigen processing, uncovering differences in antigen sensitivity to digestion by cathepsins and resistance to DM.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

Single-molecule calibrated live microscopy and computational modelling have revealed that human nuclear pore complex assembly takes different pathways during the exit from mitosis and during nuclear growth in interphase.

tRNA modifications are vital for their function in protein synthesis, one of the most central processes in all living cells. Here the authors show how KEOPS, a multi-subunit tRNA modifying complex, engages and acts on a substrate tRNA.

High dimensional quantum key distribution (QKD) systems will allow for higher key generation rate, but with added complexity for creating and detecting high dimensional quantum states. The authors demonstrate a QKD protocol using “qubit-like” qudit states, “F-qubits”, with simpler generation and detection, maintaining the benefits of high dimensional QKD protocols.

The heme degradation enzyme biliverdin IXβ reductase (BLVRB) is implicated in a redox-regulated thrombopoietic pathway. Here, the authors validate BLVRB as a cellular target by generating an orally-available small molecule inhibitor that retains platelet-enhancing functions that are mechanistically distinct from thrombopoietin receptor-targeted mimetics.

Discovery of a biochemical mechanism through which lactate binds and inhibits the SUMO protease SENP1, stimulating timed degradation of cell cycle proteins, and resulting in mitotic exit.

Cyclodipeptide oxidases are filamentous enzymes. Here, the authors dissect the mechanism of a promiscuous flavoenzyme from the biosynthesis of cyclodipeptide natural products, unveiling fast catalysis for peptide oxidation in a distinct active site.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Exotic quantum states can be advantageous for sensing, but are very fragile, so that some form of quantum error correction is needed. Here, the authors show how approximate QEC helps overcoming decoherence due to noise when measuring the excitation population of a receiver mode in a superconducting circuit.

Exon 27 of the tumor suppressor BRCA2 encodes a portion of the protein crucial for DNA repair, genome maintenance, and tumor suppression. Here the authors show that this domain binds DNA and the RAD51 recombinase to enhance the assembly of RAD51-DNA complexes.

Analysis of a set of 1,863 bursts from the repeating source FRB 20201124A provides evidence of a complicated magnetized site within about an astronomical unit from the source in a barred galaxy.

A study demonstrates the extension of a lifetime of a quantum memory using active quantum error correction and reinforcement learning.

Designed novel protein nanoparticle technology integrates antibody targeting and responds to changes in environmental conditions to release protected molecular cargoes, opening new applications for precision medicine.

A full understanding of the penetration of solar wind plasma into the Earth’s magnetosphere, during geomagnetically quiet times, remains elusive. Using multi-spacecraft data, Shi et al.find unexpected entry of the solar wind into the high-latitude magnetosphere and suggest a probable entry mechanism.

Developing disease-modifying drugs for neurodegenerative diseases has been very challenging. Now a machine learning approach has been used to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in Parkinson’s disease and other synucleinopathies. Compounds that bind to the catalytic sites on the surface of the aggregates were identified and then progressively optimized into secondary nucleation inhibitors.

In this work, authors present Kinbiont, which combines dynamical models with explainable machine learning to streamline data analysis and support theoretical formulation in microbiology.

The mechanisms involved in SLC4-mediated ion transport are still under debate. Here, the authors present a cryoEM structure of the Sodium-driven Chloride/Bicarbonate Exchanger NDCBE, which - together with computational modeling and mutagenesis - reveals molecular determinants of ion transport by SLC4.

SETDB1 is a histone methyltransferase that generates H3K9me3 marks in euchromatic regions. Here the authors show that the triple Tudor domain (3TD) of SETDB1 binds histone H3 tails containing K14 acetylation combined with K9 methylation, and that the K9me–K14ac modification defines a novel chromatin state enriched at SETDB1 binding sites.

The authors solved structures of nine native band 3-associated complexes from human red blood cell membrane by cryo-EM. Integration of structural and biochemical data supports a model of ankyrin complex assembly during erythropoiesis.

The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease.

In all experimentally observed Weyl semimetals so far, the Weyl points always appear in pairs in the momentum space. Here, the authors report one unpaired Weyl point without surface Fermi arc emerging at the center of the Brillouin zone, which is surrounded by charged Weyl nodal walls in PtGa.

Electron scattering measurements are shown to reproduce only qualitatively state-of-the-art lepton–nucleus energy reconstruction models, indicating that improvements to these particle-interaction models are required to ensure the accuracy of future high-precision neutrino oscillation experiments.

Strontium Ruthenate, Sr₂RuO₄, displays a remarkable number of intriguing physical phenomena, from superconductivity, to strain-induced ferromagnetism. Here, using low-energy muon spectroscopy, Fittipaldi et al. demonstrate the existence of unconventional magnetism at the surface of Sr₂RuO₄ in its normal state and without any applied strain.

The zinc-sensor protein Zur in a marine cyanobacterium is distinct from those in other bacteria in structure and location of its sensory zinc site, and facilitates growth across a range of zinc concentrations via activation of a metallothionein gene.

Efficient control and measurement of qubits requires them to be strongly coupled to other degrees of freedom, but this can introduce additional decoherence. Now, parametric driving makes it possible to controllably introduce and remove interactions.

In this case series of patients with T cell acute lymphoblastic leukemia (T-ALL), therapy with CD7-directed CAR T cells that express an anti-CD7 protein expression blocker to prevent CAR T-induced fratricide showed encouraging rates of clinical response and persistence of circulating CAR T cells.

Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease model.

The proton shuttle plays a critical role in the proton transfer process during lithium-mediated ammonia synthesis. Here, the authors establish the structure-activity relationship and design principles for effective proton shuttles.

A cross-reactive antibody and T cell response is identified in a large portion of patients with multisystem inflammatory syndrome in children.