Search

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

When implemented on quantum computers, lattice gauge theory should be able to address significant new scientific questions about quarks and gluons. The authors of this paper replace the traditional Cartesian lattice by one that has unique symmetry properties, and they use this new lattice to perform an error-mitigated quantum computer calculation.

The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.

CAR T cell therapies have been developed to treat paediatric diffuse intrinsic pontine glioma (DIPG), however, clinical efficacy remains limited. Here, the authors report that engineering B7-H3-targeting CAR T cells to express the chemokine receptor CXCR3-A enhances their trafficking and efficacy in DIPG preclinical models.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

pH is a critical regulator of (bio)chemical processes and therefore tightly regulated in nature. Now, proteins have been shown to possess the functionality to drive pH gradients without requiring energy input or membrane enclosure but through condensation. Protein condensates can drive unique pH gradients that modulate biochemical activity in both living and artificial systems.

Photonic time crystals (PTCs) have unveiled unusual band structures and phenomena due to temporal modulation of optical properties. Here, the authors address non-Hermitian features of PTCs within a purely Hermitian Hamiltonian description, bridging classical and quantum approaches.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Mixtures of antibiotics or pesticides can help reduce the evolution of resistance to individual compounds. Here, Comont et al. show that in blackgrass, an important agricultural weed, herbicide mixtures do reduce specialized resistance but instead can select for a generalized resistance mechanism.

Interferometers play a key role in precision measurements and metrology. Here, the authors demonstrate a new type of interferometer that replaces the standard beam splitter elements with parametric amplifiers, which provides enhanced performance compared with a Mach–Zehnder interferometer.

Single-cell RNA sequencing reveals that iris muscle, derived from neuroectoderm, can form in stem cell–derived eye organoids – enabling the modelling of iris muscle pathologies like aniridia and proliferative vitreoretinopathy.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

The charge radius of nucleons provides information about their structure. Here the authors present a method, based values of neutron electric form factors, to determine the charge radius of the neutron and provide information on improving the uncertainty of neutron charge radius measurements

Spontaneous low-frequency oscillations, which are a feature of biological systems, are challenging to engineer into microrobotic systems. The authors discover a mechanism for asymmetry-induced order and realise electrical and mechanical oscillations in a particle collective to power a microrobotic arm.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The Van Allen radiation belts are two zones of energetic particles encircling the Earth, but how electrons are accelerated to relativistic energies remains unclear. Here, the authors analyse a radiation belt event and provide evidence in favour of the ULF wave-driven radial diffusion mechanism.

Highly efficient generation of platelets in the vasculature. Here, Zhao et al. show that the mouse platelet precursor cell, megakaryocytes, generate physiological numbers of functional platelets when passaged repeatedly through pulmonary vasculature.

Methanosuratincola petrocarbonis LWZ-6 is a strict hydrogen-dependent methylotrophic methanogen that does not ferment sugars, peptides or amino acids.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

SaprotHub is a community repository for protein language models.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Cell migration through narrow constrictions during cancer metastasis significantly deforms the nucleus, creating mechanical stress on chromatin. Here, the authors reveal that such chromatin deformations lead to changes in nuclear condensates, affecting their assembly and phase behavior.

Whilst neutron scattering is a powerful tool for studying spin fluctuations in materials, its availability is limited to large-scale user facilities. Here, the authors demonstrate how the pumping of pure spin currents can be used as a desktop probe to detect an antiferromagnetic transition.

Ethanol electrosynthesis from CO reduction is achieved using an oxygen-affinity-engineered copper alloy catalyst. Unlike conventional CO dimerization pathways, which yield diverse products, this catalyst selectively promotes the CO–CH_x coupling route, enabling selective ethanol production.

In this alternative approach to quantum computation, the all-electrical operation of two qubits, each encoded in three physical solid-state spin qubits, realizes swap-based universal quantum logic in an extensible physical architecture.

Biodiversity often increases the functioning and productivity of ecosystems or communities. This work shows that such a positive diversity effect, namely overyielding in mixtures of two divergent Arabidopsis thaliana genotypes, can be genetically mapped and resolved to a single gene.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Microfluidic systems controlled by a single driving pressure are programmed to exhibit complex flow-switching schemes and a fluid analogue of Braess’s paradox by exploiting fluid inertia and network design.

Current methods to subtype brain tumors rely on invasive biopsies. Here, the authors develop a digital platform to regeneratively convert and catalytically enhance signals from rare circulating RNAs for blood-based characterization of brain tumors.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

It is hoped that simulations of molecules and materials will provide a near-term application of quantum computers. A study of the performance of error mitigation highlights the obstacles to scaling up these calculations to practically useful sizes.

Transient electronics entails the capability of electronic components to dissolve or reabsorb in a controlled manner when used in biomedical implants. Here, the authors perform a systematic study of the processes of hydrolysis, bioabsorption, cytotoxicity and immunological biocompatibility of monolayer MoS₂.

Measuring pharmacodynamics (PD) is vital for drug development but traditional PD studies are labor and resource intensive. Wu et al. introduce a kinase-modulated bioluminescent indicator for noninvasive visualization of Akt-related drug PD in living animals.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.

A system for realizing many-photon quantum circuits is presented, comprising a programmable nanophotonic chip operating at room temperature, interfaced with a fully automated control system.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures that warrant consideration as potential biosignatures.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.