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Showing 1–7 of 7 results
Advanced filters: Author: Zachary K. Wickens Clear advanced filters

  • Azoles are important synthetic targets due to their diverse applications in areas ranging from human health to food security. Now it has been shown that the hydroazolation of alkenylthianthrenium salts provides a modular platform to access diverse, densely functionalized N-alkyl azole compounds with high N-regioselectivity.

    • Céline Dorval
    • Adrian D. Matthews
    • Zachary K. Wickens
    Research
    Nature Chemistry
    Volume: 17, P: 1576-1585

  • Members of the PUF family of RNA-binding proteins bind multiple mRNAs in vivo. Here the authors show that the S. cerevisiaePuf5p binds targets of varying lengths that correlate with biological functions. The RNA-binding sites adopt different structures to adapt to a fixed protein scaffold.

    • Daniel Wilinski
    • Chen Qiu
    • Marvin Wickens
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and partner LST-1 that represses target mRNA via adjacent regulatory elements.

    • Chen Qiu
    • Sarah L. Crittenden
    • Traci M. Tanaka Hall
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • PUF (Pumilio/FBF) RNA-binding proteins and Argonaute (Ago) miRNA-binding proteins regulate mRNAs post-transcriptionally, each acting through similar yet distinct mechanisms. New genetic and biochemical analyses demonstrate that PUF and Ago proteins also function together in complex with elongation factor eEF1A to repress translation elongation.

    • Kyle Friend
    • Zachary T Campbell
    • Judith Kimble
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 176-183

  • RNA–protein interactions often depend on the recognition of extended RNA elements but the identification of these motifs is challenging. Here, the authors present a global integrated approach to analyze RNA–protein binding landscapes, mapping extended RNA interaction motifs for four RNA-binding proteins.

    • Qin Zhou
    • Nikesh Kunder
    • Zachary T. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10