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Showing 1–24 of 24 results
Advanced filters: Author: Zachary W. Bent Clear advanced filters

  • Genetic mapping in mice identified Homer1a as a key modifier of attention. Developmental downregulation in the prefrontal cortex enhances inhibitory tone, neural signal to noise and adult attentional performance, revealing a new control mechanism and target.

    • Zachary Gershon
    • Alessandra Bonito-Oliva
    • Priya Rajasethupathy
    Research
    Nature Neuroscience
    P: 1-13

  • One-dimensional linear carbon chains reaching a length close to 800 nm have been synthesized at high temperature and high vacuum using double-walled carbon nanotubes as nanoreactors.

    • Lei Shi
    • Philip Rohringer
    • Thomas Pichler
    Research
    Nature Materials
    Volume: 15, P: 634-639

  • Calculations suggest that ion transport through nanochannels is significantly modified as the diameter approaches molecular dimensions. Choi et al.introduce a single-nanotube platform to demonstrate this effect and find a maximum ion transport rate at a diameter of approximately 1.6 nm.

    • Wonjoon Choi
    • Zachary W. Ulissi
    • Michael S. Strano
    Research
    Nature Communications
    Volume: 4, P: 1-8

  • Chemical experiments on californium are stymied by isotope availability and radioactivity considerations, but are advanced here with synthesis and characterization of an organometallic complex.

    • Conrad A. P. Goodwin
    • Jing Su
    • Joseph W. Ziller
    Research
    Nature
    Volume: 599, P: 421-424

  • The main components of the prokaryotic chemotaxis system, chemoreceptors, organize into a hexagonal (P6 symmetry) extended array. Here authors use cryo-ET and report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organization of the histidine kinase CheA in Treponema denticola cells.

    • Alise R. Muok
    • Davi R. Ortega
    • Ariane Briegel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Single-nuclear transcriptomic and proteomic analyses identify molecular characteristics shared by multiple classes of congenital heart disease, including phenotypes associated with insulin resistance.

    • Matthew C. Hill
    • Zachary A. Kadow
    • James F. Martin
    Research
    Nature
    Volume: 608, P: 181-191

  • Theriot and colleagues use fish keratocytes to study variations in cell shape that occur during motility. They report a model that quantitatively accounts for their experimental measurements and provides an explanation for the observed morphology of motile cells.

    • Kinneret Keren
    • Zachary Pincus
    • Julie A. Theriot
    Research
    Nature
    Volume: 453, P: 475-480

  • Solvent plays a critical role in electron-transfer reactions, but short-range solvation dynamics are challenging to observe. Now, femtosecond X-ray solution scattering has been used to directly monitor the reorganization of water upon ultrafast intramolecular electron transfer in a bimetallic complex. Coherent motions of the first-shell water molecules are observed, arising from changes in solute–solvent hydrogen bonding.

    • Elisa Biasin
    • Zachary W. Fox
    • Munira Khalil
    Research
    Nature Chemistry
    Volume: 13, P: 343-349

  • Perovskite solar cells can complement silicon photovoltaics in multijunction devices. Here, the authors optimize light harvesting in monolithic perovskite-on-silicon devices and fabricate a certified 23.6% efficient, 1 cm2 tandem solar cell with a perovskite device that withstands damp heat tests.

    • Kevin A. Bush
    • Axel F. Palmstrom
    • Michael D. McGehee
    Research
    Nature Energy
    Volume: 2, P: 1-7

  • Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

    • Catherine M Phelan
    • Karoline B Kuchenbaecker
    • Paul D P Pharoah
    Research
    Nature Genetics
    Volume: 49, P: 680-691

  • A multi-omic atlas of breast cancers, integrating single-cell RNA sequencing, spatial transcriptomics and immunophenotyping, identifies nine ecotypes associated with cellular heterogeneity and prognosis.

    • Sunny Z. Wu
    • Ghamdan Al-Eryani
    • Alexander Swarbrick
    Research
    Nature Genetics
    Volume: 53, P: 1334-1347

  • Alternative RNA splicing varies across the brain. Its mapping at single cell resolution is unclear. Here, the authors provide a spatial and single-cell splicing atlas reporting brain region- and cell type-specific expression of different isoforms in the postnatal mouse brain.

    • Anoushka Joglekar
    • Andrey Prjibelski
    • Hagen U. Tilgner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Single-cell gene expression analysis is challenging. This work describes a new droplet-based single cell RNA-seq platform capable of processing tens of thousands of cells across 8 independent samples in minutes, and demonstrates cellular subtypes and host–donor chimerism in transplant patients.

    • Grace X. Y. Zheng
    • Jessica M. Terry
    • Jason H. Bielas
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Microbial symbioses can help plants mitigate environmental stresses and plant microbiome compositions are influenced, for example, by drought stress. The investigated temporal shifts of the rice root microbiome under various durations of drought show the progression of microbiome composition in response to stress and a long-lasting effect of severe conditions.

    • Christian Santos-Medellín
    • Zachary Liechty
    • Venkatesan Sundaresan
    Research
    Nature Plants
    Volume: 7, P: 1065-1077

  • In this study, the authors report the identification, biochemical characterization and cryo-electron microscopy structure of a phage-encoded miniature type V CRISPR-Cas nuclease in different functional states. This work provides mechanistic insight into CRISPR-Cas12 nucleases and a solid framework for future rational engineering.

    • Satoshi N. Omura
    • Lauren E. Alfonse
    • Osamu Nureki
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-15

  • Laser-induced Coulomb explosion imaging allows the study of molecular geometries over time, but the results are often distorted by ultrafast motion during the ionizing laser pulse. Here, the authors film the rapid slingshot motion in D2O that induces this distortion and elucidate the underlying mechanism of enhanced ionization.

    • Andrew J. Howard
    • Mathew Britton
    • Philip H. Bucksbaum
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • Crystal structures of the DNA glycosylase AlkD with DNA containing various modified bases show that neither substrate recognition nor catalysis use a base-flipping mechanism; instead, AlkD scans the phosphodeoxyribose backbone for increased cationic charge imparted by the alkylated base, and then uses the positive charge to facilitate cleavage of the glycosidic bond, thus explaining the specificity of AlkD for cationic lesions.

    • Elwood A. Mullins
    • Rongxin Shi
    • Brandt F. Eichman
    Research
    Nature
    Volume: 527, P: 254-258