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Advanced filters: Author: Zeinab Abbaszadeh Clear advanced filters

Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies

B cell malignancies resistant to conventional treatments are potentially sensitive to CAR-T cell immune therapy, but its clinical applicability is limited by immune related adverse effects. Here authors show in a humanized mouse model that blocking IFNγ with the monoclonal antibody emapalumab mitigates the adverse effects of CAR.CD19-T cells without compromising their anti-lymphoma efficacy.

Simona Manni
Francesca Del Bufalo
Concetta Quintarelli
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Ultrasound-assisted encapsulating folic acid-based carbon quantum dots within breast cancer cell-derived exosomes as a co-receptors-mediated anticancer nanocarrier for enhanced breast cancer therapy

Fahimeh Kazeminava
Siamak Javanbakht
Mohammad Nouri
ResearchOpen Access23 Jul 2024
Scientific Reports

Volume: 14, P: 1-12
MicroRNAs delivery into human cells grown on 3D-printed PLA scaffolds coated with a novel fluorescent PAMAM dendrimer for biomedical applications

Alessandro Paolini
Luca Leoni
Andrea Masotti
ResearchOpen Access17 Sept 2018
Scientific Reports

Volume: 8, P: 1-11

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