Biopharmaceutical drugs, including therapeutic proteins and nucleic acids, are becoming increasingly prominent in modern medicine, offering promising solutions for treating major diseases that are difficult to address with traditional small-molecule drugs. Recently, multicomponent reaction (MCR)-based combinatorial chemistry has emerged as a powerful approach for designing protein or nucleic acid delivery materials, enabling the rapid generation of large materials libraries for structure-activity relationships investigation. In this perspective, we discuss the design principles of these delivery materials, summarize recent advances, and propose future directions for using the MCR-based combinatorial chemistry to develop next-generation biomacromolecule delivery systems.
- Zepeng He
- Zhicheng Le
- Yongming Chen
