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Showing 1–8 of 8 results

Advanced filters: Author: Zhaoqing Ba Clear advanced filters

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

Using an auxin-inducible approach, the authors show that downmodulation of CTCF activity promotes cohesin-driven RAG endonuclease scanning, and thus V(D)J recombination, across the Igh locus.

Zhaoqing Ba
Jiangman Lou
Frederick W. Alt
Research27 Jul 2020
Nature

Volume: 586, P: 305-310
Bioinspired and biointegrated vision for artificial sight convergence

The historically independent evolution of bioinspired and biointegrated vision is increasingly showing a trend of convergence. This Review discusses each technological framework emphasizing visual devices that mimic the structures of the natural eyes and the information-processing capabilities of biological visual systems.

Yifei Yang
Yifei Wang
Yang Chai
Reviews25 Jun 2025
Nature Reviews Bioengineering

P: 1-16
Molecular basis for differential Igk versus Igh V(D)J joining mechanisms

Experiments in mouse models, and in cell lines that only allow primary Vκ-to-Jκ rearrangements, enable characterization of the mechanisms of V(D)J recombination.

Yiwen Zhang
Xiang Li
Hongli Hu
ResearchOpen Access29 May 2024
Nature

Volume: 630, P: 189-197
Loop extrusion mediates physiological Igh locus contraction for RAG scanning

Long-distance V(D)J recombination is facilitated by contraction of the Igh locus and linear RAG scanning along chromatin, both driven by cohesin-mediated loop extrusion, which allows recombination of widely separated gene segments to occur.

Hai-Qiang Dai
Hongli Hu
Frederick W. Alt
Research13 Jan 2021
Nature

Volume: 590, P: 338-343
BCR selection and affinity maturation in Peyer’s patch germinal centres

An analysis of the immunoglobulin repertoire of B cells in Peyer’s patch germinal centres in mice provides evidence for the selection of B cell receptor clonotypes by gut antigens and antigen-driven affinity maturation.

Huan Chen
Yuxiang Zhang
Frederick W. Alt
Research06 May 2020
Nature

Volume: 582, P: 421-425
Fundamental roles of chromatin loop extrusion in antibody class switching

Chromatin loop extrusion has fundamental mechanistic roles in immunoglobulin heavy chain class switch recombination.

Xuefei Zhang
Yu Zhang
Frederick W. Alt
Research30 Oct 2019
Nature

Volume: 575, P: 385-389
The fundamental role of chromatin loop extrusion in physiological V(D)J recombination

V(D)J recombination in B cells involves cohesin-mediated extrusion of chromatin loops to present DNA targets for cleavage and joining.

Yu Zhang
Xuefei Zhang
Frederick W. Alt
Research11 Sept 2019
Nature

Volume: 573, P: 600-604
Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

Min Gao
Wei Wei
Jannie M Rendtlew Danielsen
ResearchOpen Access25 Mar 2014
Cell Research

Volume: 24, P: 532-541