Nature Search

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

Aging leads to impaired differentiation and increased pool size of hematopoietic stem cells (HSCs). Here, the authors show that wild-type p53-induced phosphatase 1 (Wip1), a negative regulator of DNA damage response pathways, regulates aging-associated HSC differentiation and expansion viap53 and mTORC1 pathways, respectively.

Zhiyang Chen
Weiwei Yi
Zhenyu Ju
Research16 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Apatinib plus hepatic arterial infusion of oxaliplatin and raltitrexed for hepatocellular carcinoma with extrahepatic metastasis: phase II trial

Locoregional treatment of hepatocellular carcinoma (HCC) using hepatic arterial infusion chemotherapy (HAIC) has been shown to be effective. Here the authors conduct a phase II clinical trial evaluating the efficacy and safety of combining apatinib (VEGFR2 inhibitor) and HAIC (oxaliplatin plus raltitrexed) in patients with advanced HCC with extrahepatic metastasis.

Shiguang Chen
Xiangdong Wang
Chuanben Chen
ResearchOpen Access14 Oct 2024
Nature Communications

Volume: 15, P: 1-10
Doping effects of indium and copper on ferromagnetism in N-type magnetic semiconductor Ba(Zn,Co)₂As₂

Xueqin Zhao
Jinou Dong
Fanlong Ning
ResearchOpen Access28 Mar 2025
Scientific Reports

Volume: 15, P: 1-8
Flat bands, non-trivial band topology and rotation symmetry breaking in layered kagome-lattice RbTi₃Bi₅

Kagome superconductors are a platform for intertwined condensed matter phenomena that may be mediated by band topology. Here, authors use ARPES and DFT to identify type-II Dirac nodal lines, flat bands, topologically non-trivial surface states and signatures of nematicity in the kagome compound RbTi₃Bi₅.

Zhicheng Jiang
Zhengtai Liu
Dawei Shen
ResearchOpen Access14 Aug 2023
Nature Communications

Volume: 14, P: 1-8
Discovery of \({\hat{\boldsymbol{C}}}_2\) rotation anomaly in topological crystalline insulator SrPb

New class of topological crystalline insulators (TCI) have been proposed, but are yet to be experimentally evidenced. Here, the authors evidence two massless Dirac fermions protected by the combination of time-reversal symmetry T and Ĉ_2y on the (010) surface of SrPb, confirming the Ĉ₂ rotation anomaly in the new class of TCIs.

Wenhui Fan
Simin Nie
Hong Ding
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-7
Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

Forkhead transcription factor FoxF2 plays a crucial role in the development of organs derived from primitive gut. Here the authors show that reduction of Foxf2 expression in stromal cells is associated with high grade prostate cancer and that increasing prostatic stromal Foxf2 sensitizes prostate cancer to immune checkpoint blockade.

Deyong Jia
Zhicheng Zhou
Li Xin
ResearchOpen Access11 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy

Kaisa Cui
Bingxin Liu
Xiaojie Lu
ResearchOpen Access11 Jul 2025
British Journal of Cancer

Volume: 133, P: 756-770
Long noncoding RNA MALAT1 suppresses breast cancer metastasis

Targeted inactivation, restoration and overexpression of MALAT1 in multiple in vivo models demonstrate that the lncRNA MALAT1 suppresses breast cancer metastasis through binding and inactivation of the pro-metastatic transcription factor TEAD.

Jongchan Kim
Hai-Long Piao
Li Ma
Research22 Oct 2018
Nature Genetics

Volume: 50, P: 1705-1715
SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

Here, the authors provide evidence that SARS-CoV-2 N protein leads to autophagic degradation of Dicer, XPO5, SRSF3, and hnRNPA3, inducing DNA damage and proteotoxic stress, eventually causing pneumonia. The small-molecule drug PJ34 or anastrozole alleviates N protein-induced pneumonia.

Yu-Wei Luo
Jiang-Peng Zhou
Kai-Fu Tang
ResearchOpen Access13 Aug 2024
Nature Communications

Volume: 15, P: 1-23
FBX8 promotes metastatic dormancy of colorectal cancer in liver

Xiaohui Zhu
Feifei Wang
Li Liang
ResearchOpen Access14 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-15
Observation of unconventional chiral fermions with long Fermi arcs in CoSi

Angle-resolved photoemission spectroscopy measurements in CoSi reveal the presence of unconventional chiral fermions near the Fermi level, with giant surface Fermi arcs and one pair of well separated chiral nodes.

Zhicheng Rao
Hang Li
Hong Ding
Research20 Mar 2019
Nature

Volume: 567, P: 496-499
Cassava genome from a wild ancestor to cultivated varieties

Cassava is a major source of food in tropical and subtropical regions. Here the authors sequence the genomes of wild and domesticated cassava varieties and identify genes that have been selected for and against during the evolution and domestication of this economically important crop.

Wenquan Wang
Binxiao Feng
Ming Peng
ResearchOpen Access10 Oct 2014
Nature Communications

Volume: 5, P: 1-9
CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1

Hong Luo
Zhicheng Zhou
Peijing Zhang
ResearchOpen Access30 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-11
Transcriptomic and metabolomic analyses reveal that melatonin promotes melon root development under copper stress by inhibiting jasmonic acid biosynthesis

Zhicheng Hu
Qiushi Fu
Huaisong Wang
ResearchOpen Access01 Jun 2020
Horticulture Research

Volume: 7, P: 1-15
Deep-learning augmented RNA-seq analysis of transcript splicing

DARTS first uses public domain data to train a deep neural network to predict differential alternative splicing; the predictions are then combined with observed RNA-seq data in a Bayesian framework to infer changes in alternative splicing between biological samples.

Zijun Zhang
Zhicheng Pan
Yi Xing
Research25 Mar 2019
Nature Methods

Volume: 16, P: 307-310
Association between estimated glucose disposal rate and gallstone risk in US adults based on NHANES 2017 to 2020

Zhiying Wang
Xue Zhang
Yan Jiao
ResearchOpen Access21 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
DPA-2: a large atomic model as a multi-task learner

Duo Zhang
Xinzijian Liu
Han Wang
ResearchOpen Access19 Dec 2024
npj Computational Materials

Volume: 10, P: 1-15
Limits on the luminance of dark matter from xenon recoil data

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

Xuyang Ning
Abdusalam Abdukerim
Yubo Zhou
Research17 May 2023
Nature

Volume: 618, P: 47-50
Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth

Zhicheng Zhou
Deyong Jia
Li Xin
Research03 Jul 2023
Oncogene

Volume: 42, P: 2428-2438
Strategies for ear elevation and the treatment of relevant complications in autologous cartilage microtia reconstruction

Zhicheng Xu
Yiyuan Li
Xia Chen
ResearchOpen Access08 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae

The protein phosphatase 4 complex, the Snf1 kinase, and the transcriptional regulators CreA and Crf1 collaboratively control carbon catabolite repression and de-repression in the rice blast fungus Magnaporthe oryzae.

Zhicheng Huang
Qing Wang
Jianping Lu
ResearchOpen Access28 Jan 2025
Communications Biology

Volume: 8, P: 1-16
Telecom-band multiwavelength vertical emitting quantum well nanowire laser arrays

An innovative multi-step facet engineering approach was developed to achieve InGaAs/InP quantum well nanowire arrays with conttolled dimensions, uniform morphology and high crystal quality, enabling low-threshold lasing in the telecom-band.

Xutao Zhang
Fanlu Zhang
Lan Fu
ResearchOpen Access04 Sept 2024
Light: Science & Applications

Volume: 13, P: 1-9
Electroporation-mediated novel albumin-fused Flt3L DNA delivery promotes cDC1-associated anticancer immunity

Ming-Hung Hu
Darrell Fan
Chien-Fu Hung
Research29 Oct 2024
Gene Therapy

Volume: 32, P: 277-286
Spatial mapping of cellular senescence: emerging challenges and opportunities

SenNet Consortium members review current and emerging methodologies for spatially resolved mapping of senescent cells. They discuss their limitations and challenges involved in the aim of creating a comprehensive atlas of senescent cells during aging.

Aditi U. Gurkar
Akos A. Gerencser
João F. Passos
Reviews03 Jul 2023
Nature Aging

Volume: 3, P: 776-790
Inhibition of CCL7 derived from Mo-MDSCs prevents metastatic progression from latency in colorectal cancer

Xiaoli Ren
Jianbiao Xiao
Li Liang
ResearchOpen Access13 May 2021
Cell Death & Disease

Volume: 12, P: 1-15
Combining single-cell and bulk RNA sequencing, NK cell marker genes reveal a prognostic and immune status in pancreatic ductal adenocarcinoma

Yonghao Ouyang
Rongxi Shen
Xin Chen
ResearchOpen Access01 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Mutual communication between radiosensitive and radioresistant esophageal cancer cells modulates their radiosensitivity

Congying Xie
Xiao Chen
Kai-Fu Tang
ResearchOpen Access19 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-14
Bulk CsPbCl_xBr_3-x (1 ≤ x ≤ 3) perovskite nanocrystals/polystyrene nanocomposites with controlled Rayleigh scattering for light guide plate

High transparent perovskite nanocrystals/polystyrene nanocomposites can be fabricated by a two-type ligand strategy and have enormous potential to serve as a new kind of light guide plate.

Chongming Liu
Zhicheng Zhu
Bai Yang
ResearchOpen Access01 Nov 2023
Light: Science & Applications

Volume: 12, P: 1-12
Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

Yan-Xia Wang
Haibo Wu
Xiu-Wu Bian
ResearchOpen Access11 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-15
Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide

Moon Jung Back
Hae Chan Ha
Dae Kyong Kim
ResearchOpen Access04 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-18
Artificial intelligence defines protein-based classification of thyroid nodules

Yaoting Sun
Sathiyamoorthy Selvarajan
Tiannan Guo
ResearchOpen Access06 Sept 2022
Cell Discovery

Volume: 8, P: 1-17
The FOXM1–ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells

Youxiang Hou
Qianling Zhu
Xiong Li
ResearchOpen Access09 Mar 2017
Cell Death & Disease

Volume: 8, P: e2659
APP upregulation contributes to retinal ganglion cell degeneration via JNK3

Chao Liu
Cheng-Wu Zhang
Gavin S. Dawe
ResearchOpen Access13 Dec 2017
Cell Death & Differentiation

Volume: 25, P: 663-678
WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway

Lingli Guo
Tao Wang
Fu-Qiang Wen
Research31 Aug 2015
Laboratory Investigation

Volume: 96, P: 218-229

Search

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

Apatinib plus hepatic arterial infusion of oxaliplatin and raltitrexed for hepatocellular carcinoma with extrahepatic metastasis: phase II trial

Doping effects of indium and copper on ferromagnetism in N-type magnetic semiconductor Ba(Zn,Co)₂As₂

Flat bands, non-trivial band topology and rotation symmetry breaking in layered kagome-lattice RbTi₃Bi₅

Discovery of \({\hat{\boldsymbol{C}}}_2\) rotation anomaly in topological crystalline insulator SrPb

Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy

Long noncoding RNA MALAT1 suppresses breast cancer metastasis

SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

FBX8 promotes metastatic dormancy of colorectal cancer in liver

Observation of unconventional chiral fermions with long Fermi arcs in CoSi

Cassava genome from a wild ancestor to cultivated varieties

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1

Transcriptomic and metabolomic analyses reveal that melatonin promotes melon root development under copper stress by inhibiting jasmonic acid biosynthesis

Deep-learning augmented RNA-seq analysis of transcript splicing

Association between estimated glucose disposal rate and gallstone risk in US adults based on NHANES 2017 to 2020

DPA-2: a large atomic model as a multi-task learner

Limits on the luminance of dark matter from xenon recoil data

Androgen-regulated stromal complement component 7 (C7) suppresses prostate cancer growth

Strategies for ear elevation and the treatment of relevant complications in autologous cartilage microtia reconstruction

A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae

Telecom-band multiwavelength vertical emitting quantum well nanowire laser arrays

Electroporation-mediated novel albumin-fused Flt3L DNA delivery promotes cDC1-associated anticancer immunity

Spatial mapping of cellular senescence: emerging challenges and opportunities

Inhibition of CCL7 derived from Mo-MDSCs prevents metastatic progression from latency in colorectal cancer

Combining single-cell and bulk RNA sequencing, NK cell marker genes reveal a prognostic and immune status in pancreatic ductal adenocarcinoma

Mutual communication between radiosensitive and radioresistant esophageal cancer cells modulates their radiosensitivity

Bulk CsPbCl_xBr_3-x (1 ≤ x ≤ 3) perovskite nanocrystals/polystyrene nanocomposites with controlled Rayleigh scattering for light guide plate

Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide

Artificial intelligence defines protein-based classification of thyroid nodules

The FOXM1–ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells

APP upregulation contributes to retinal ganglion cell degeneration via JNK3

WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway

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