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Showing 1–4 of 4 results

Advanced filters: Author: Zhifen Cui Clear advanced filters

Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection

Using a Cas13d-based nanosystem to knockdown lung protease cathepsin L, Cui et al. demonstrated that CRISPR–Cas system can be used to prevent and treat SARS-CoV-2 infection by targeting mRNA of host genes.

Zhifen Cui
Cong Zeng
Qianben Wang
Research25 Jul 2022
Nature Chemical Biology

Volume: 18, P: 1056-1064
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors

Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.

Zhifen Cui
Yu Zhang
Chunhai Fan
ResearchOpen Access19 Oct 2018
Nature Communications

Volume: 9, P: 1-11
Integrative analysis identifies the atypical repressor E2F8 as a targetable transcriptional activator driving lethal prostate cancer

Furong Huang
Kexin Li
Qianben Wang
Research29 Nov 2024
Oncogene

Volume: 44, P: 481-493
USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

Zhifen Yang
Huifang Xian
Jun Cui
ResearchOpen Access04 Aug 2015
Scientific Reports

Volume: 5, P: 1-15