Spatiotemporally activating DC cells in lymph nodes (LN) for cancer vaccine therapy remains a challenge. Here the authors combine antigen loaded STING nanoadjuvants with LN-confined laser or ultrasound stimulation to activate DC cells, sequentially enhances antigen-specific CD8+ T cell response and reduces tumor size.
- Fangmin Chen
- Huijuan Zhang
- Haijun Yu
