Nature Search

Sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer: a randomized phase 3 trial

In the OptiTROP-Breast01 phase 3 trial, patients with metastatic triple-negative breast cancer who received the TROP2-targeted antibody–drug conjugate sacituzumab tirumotecan experienced longer progression-free survival than patients treated with chemotherapy.

Yongmei Yin
Ying Fan
Binghe Xu
Research11 Apr 2025
Nature Medicine

Volume: 31, P: 1969-1975
Bireociclib plus fulvestrant for HR+/HER2- advanced female breast cancer progressed on or after endocrine therapy: phase 3 BRIGHT-2 study interim analysis

While CDK4/6 inhibitors have become standard of care in patients with HR+/HER2- advanced breast cancer (ABC), selecting the optimal inhibitor could improve care further. Here, the authors report planned interim analysis of the BRIGHT-2 study, a randomised phase 3 trial comparing bireociclib (CDK4/6i) and fulvestrant (ET) against placebo and fulvestrant in female HR + /HER2- ABC patients.

Jiayu Wang
Qingyuan Zhang
Binghe Xu
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-9
Monthly precipitation prediction based on quadratic decomposition and improved parrot algorithm

Weijie Zhang
Yuming Zeng
Rusheng Zhou
ResearchOpen Access21 Jul 2025
Scientific Reports

Volume: 15, P: 1-25
Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial

CDK4/6 inhibition is often effective for those with breast cancer but success is limited by adverse reactions. Here, the authors report a phase III randomised trial comparing fulvestrant (oestrogen receptor antagonist) with or without lerociclib (CDK4/6 inhibitor) for the treatment of hormone receptor-positive HER2-negative, endocrine-resistant advanced breast cancer.

Binghe Xu
Qingyuan Zhang
Tong Li
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-9
Landscape of somatic alterations in large-scale solid tumors from an Asian population

Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.

Liqun Wu
Herui Yao
Minghui Wang
ResearchOpen Access23 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Correction: DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration

Yixin Tong
Yuan Huang
Dongming Lai
Amendments and CorrectionsOpen Access16 Jun 2021
Cell Death & Disease

Volume: 12, P: 1
HER2-targeting antibody drug conjugate FS-1502 in HER2-expressing metastatic breast cancer: a phase 1a/1b trial

Safety concerns limit the success of HER2-targeting antibody-drug conjugates (ADCs) for the treatment of HER2-postive breast cancer. Here, the authors present a phase 1a/b trial reporting the safety and preliminary efficacy of FS-1502, an anti-HER2 ADC with a cancer-selective cleavable linker, for the treatment of HER2-positive metastatic breast cancer.

Qiao Li
Ying Cheng
Binghe Xu
ResearchOpen Access17 Jun 2024
Nature Communications

Volume: 15, P: 1-10
Dalpiciclib or placebo plus fulvestrant in hormone receptor-positive and HER2-negative advanced breast cancer: a randomized, phase 3 trial

In the multicenter, phase 3 DAWNA-1 trial, the combination of dalpiciclib, a new cyclin-dependent kinase 4 and 6 inhibitor, with fulvestrant, in patients with HR⁺HER2⁻ advanced breast cancer who progressed or relapsed on endocrine therapy, improved progression-free survival with manageable safety and may represent a new treatment option.

Binghe Xu
Qingyuan Zhang
Jianjun Zou
Research04 Nov 2021
Nature Medicine

Volume: 27, P: 1904-1909
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Fang Qiu
Ruqi Tang
Xiong Ma
ResearchOpen Access20 Apr 2017
Nature Communications

Volume: 8, P: 1-8
A real world analysis of secondary BRAF variations after targeted therapy resistance in driver gene positive NSCLC

DuJiang Liu
KaiBo Ding
YanJun Xu
ResearchOpen Access01 Sept 2024
Scientific Reports

Volume: 14, P: 1-12
RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer

R-spondin 2 has an important role in development but its function in cancer has not been described. In this study, Wu et al. demonstrate that R-spondin 2 is decreased in expression in colorectal cancer and this is associated with promoter methylation and inhibition of Wnt signalling.

Changjie Wu
Sunquan Qiu
Xincheng Lu
Research30 Jan 2014
Nature Communications

Volume: 5, P: 1-13
ACE-Breast-02: a randomized phase III trial of ARX788 versus lapatinib plus capecitabine for HER2-positive advanced breast cancer

Xichun Hu
Qingyuan Zhang
Yuan Lei
ResearchOpen Access17 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-9
DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration

Yixin Tong
Yuan Huang
Dongming Lai
ResearchOpen Access22 May 2021
Cell Death & Disease

Volume: 12, P: 1-12
Identification of a novel Cys146X mutation of SOD1 in familial amyotrophic lateral sclerosis by whole-exome sequencing

Jinyu Wu
Enjian Shen
Tao Cai
Research17 May 2012
Genetics in Medicine

Volume: 14, P: 823-826
IFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway

Zhangsheng Xiong
Xiangdong Xu
Yang Liu
ResearchOpen Access13 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-11
Side-chain Engineering of Benzo[1,2-b:4,5-b’]dithiophene Core-structured Small Molecules for High-Performance Organic Solar Cells

Xinxing Yin
Qiaoshi An
Weihua Tang
ResearchOpen Access03 May 2016
Scientific Reports

Volume: 6, P: 1-10
SCD5 expression correlates with prognosis and response to neoadjuvant chemotherapy in breast cancer

Weipeng Zhao
Linlin Sun
Zhongsheng Tong
ResearchOpen Access26 Apr 2021
Scientific Reports

Volume: 11, P: 1-11
Comprehensive characterization of posttranscriptional impairment-related 3′-UTR mutations in 2413 whole genomes of cancer patients

Wenqing Wei
Wenyan Gao
Zhihua Liu
ResearchOpen Access02 Jun 2022
npj Genomic Medicine

Volume: 7, P: 1-12
Understanding population structure and historical demography of Litsea auriculata (Lauraceae), an endangered species in east China

Qifang Geng
Lin Sun
Chunlan Lian
ResearchOpen Access11 Dec 2017
Scientific Reports

Volume: 7, P: 1-16
Genetic evidence of gender difference in autism spectrum disorder supports the female-protective effect

Yi Zhang
Na Li
Zhongsheng Sun
ResearchOpen Access15 Jan 2020
Translational Psychiatry

Volume: 10, P: 1-10
Effects of anti-H. pylori triple therapy and a probiotic complex on intestinal microbiota in duodenal ulcer

Lili Wu
Zikai Wang
Yunsheng Yang
ResearchOpen Access06 Sept 2019
Scientific Reports

Volume: 9, P: 1-11
A comparative study of the genetic components of three subcategories of autism spectrum disorder

Jinchen Li
Shanshan Hu
Zhongsheng Sun
Research06 Jun 2018
Molecular Psychiatry

Volume: 24, P: 1720-1731
Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD

Jun Guo
Lun Cai
Jie Du
ResearchOpen Access14 Aug 2015
Scientific Reports

Volume: 5, P: 1-10
Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing

Jing Xu
Zhongshan Li
Qiming Dai
ResearchOpen Access17 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
Critical roles of G protein-coupled receptors in regulating intestinal homeostasis and inflammatory bowel disease

Zhongsheng Feng
Ruicong Sun
Zhanju Liu
Reviews22 Jun 2022
Mucosal Immunology

Volume: 15, P: 819-828
PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway

Yan Zhang
Yi Ba
Chen-Yu Zhang
Research20 Mar 2007
Cell Research

Volume: 17, P: 363-373

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Sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer: a randomized phase 3 trial

Bireociclib plus fulvestrant for HR+/HER2- advanced female breast cancer progressed on or after endocrine therapy: phase 3 BRIGHT-2 study interim analysis

Monthly precipitation prediction based on quadratic decomposition and improved parrot algorithm

Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial

Landscape of somatic alterations in large-scale solid tumors from an Asian population

Correction: DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration

HER2-targeting antibody drug conjugate FS-1502 in HER2-expressing metastatic breast cancer: a phase 1a/1b trial

Dalpiciclib or placebo plus fulvestrant in hormone receptor-positive and HER2-negative advanced breast cancer: a randomized, phase 3 trial

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

A real world analysis of secondary BRAF variations after targeted therapy resistance in driver gene positive NSCLC

RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer

ACE-Breast-02: a randomized phase III trial of ARX788 versus lapatinib plus capecitabine for HER2-positive advanced breast cancer

DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration

Identification of a novel Cys146X mutation of SOD1 in familial amyotrophic lateral sclerosis by whole-exome sequencing

IFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway

Side-chain Engineering of Benzo[1,2-b:4,5-b’]dithiophene Core-structured Small Molecules for High-Performance Organic Solar Cells

SCD5 expression correlates with prognosis and response to neoadjuvant chemotherapy in breast cancer

Comprehensive characterization of posttranscriptional impairment-related 3′-UTR mutations in 2413 whole genomes of cancer patients

Understanding population structure and historical demography of Litsea auriculata (Lauraceae), an endangered species in east China

Genetic evidence of gender difference in autism spectrum disorder supports the female-protective effect

Effects of anti-H. pylori triple therapy and a probiotic complex on intestinal microbiota in duodenal ulcer

A comparative study of the genetic components of three subcategories of autism spectrum disorder

Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD

Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing

Critical roles of G protein-coupled receptors in regulating intestinal homeostasis and inflammatory bowel disease

PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway

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