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Induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated from adult cells by reprogramming. iPSCs have the same properties as embryonic stem cells, and therefore self-renew and can differentiate into all cell types of the body except for cells in extra-embryonic tissues such as the placenta.
This Protocol Extension details the standardized production of iPS cell-derived macrophages in an intermediate-scale benchtop bioreactor, providing a valuable tool for academic labs focused on human immune cells.
This study provides a comprehensive profile of human fetal midbrain development and its comparison with lab-grown midbrain cultures. These findings demonstrate that midbrain organoids recapitulate fetal developmental stages while capturing essential spatial and molecular characteristics, relevant to dopamine-related disorders.
Multiomic single-cell analyses of 15 Down syndrome fetal cortical samples identify widespread disruption of neurodevelopmental transcriptional programs, driven by three dosage-sensitive chromosome 21 transcription factors.
Functional CD4+ invariant Natural Killer T cells were induced from iPSCs using the Artificial Thymic Organoid method. It showed antigen specific adjuvant function and ability to release T cell suppression by M2 macrophage.
In this Tools of the Trade article, Wang and Cheng (Deng Lab) describe an improved protocol for the generation of human pluripotent stem cells by chemical reprogramming based on the targeting of epigenetic obstacles.
