Transgenic organisms articles from across Nature Portfolio

This study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytes’ role in neuroinflammation and cognition without the use of viral transduction, mitigating the potential side effects associated with standard techniques.

A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.

Increased cardiac fibulin-4 expression in response to TAC-induced pressure overload protects against cardiac hypertrophy in mouse hearts.

Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

FlipFlop mice harbor functionally reversed T cells due to a switch in CD4 and CD8 expression.

Jellyfish are established as a model system for neuroscience.