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    Channelopathies are diseases that result from functional disturbances of ion channels or the proteins that regulate them. The June special issue brings together a selection of articles dealing with the various ion channels, including aquaporins, potassium channels, chloride channels, sodium channels and calcium channels, that are involved in maladies such as cardiovascular disease, brain injury, reproductive disease and kidney disease and the recent advances that have been made in identifying potential drug targets for treating these diseases. The accompanying web focus presents additional links to related articles in this area from across Nature Publishing Group.

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    The October special issue on vascular biology and vascular disease brings together the latest reviews and articles in the field. Together with this web focus APS delves into our current understanding and investigates recent advances in various aspects of vascular injury, including vascular stiffness, vascular aging, phenotypic alteration, lipid transportation, and endothelium dysfunction.

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    The 30th Anniversary Special Issue (September 2010) of APS brings together a series of thought-provoking Perspectives, Reviews and Original Articles on various outstanding issues in pharmacology today. This accompanying web focus provides a collection of recent developments in these fields. Select articles have been set free for a limited time.

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    Nicotinic acetylcholine receptors (nAChRs) are a superfamily of ligand-gated ion channels which mediate nicotine reward, dependence and addiction. Throughout the central nervous system, neuronal nAChRs exist as multiple, diverse subtypes comprising unique pentamers of genetically distinct subunits. These subtypes each exhibit different function and pharmacology, but their precise roles in nicotine addiction remain elusive. This special issue and accompanying web focus provide an overview of the possible mechanisms of different nAChR subtypes in the mediation of nicotine reward and reinforcement.

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    Spanning a range of topics from bioengineering to neuropharmacology, cardiovascular pharmacology, cancer chemoprevention research and calcium signaling, APS is proud to present a collection of top review articles from recent years, as chosen by the editor. Complementing this collection, the January issue also includes the latest reviews covering various aspects of pharmacology.

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