Abstract
Atopy is a common and genetically heterogeneous syndrome predisposing to allergic asthma and rhinitis. A locus linked to the atopy phenotype has been shown to be present on chromosome 11q12-13. Linkage has only been seen in maternally derived alleles. We have constructed a genetic linkage map of the region, using 15 markers to span approximately 27 cM, and integrate previously published maps. Under a model of maternal inheritance, the atopy locus is placed within a 7-cM interval between D11S480 and D11S451. The interval contains the important candidate gene FCERIB.
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Sandford, A.J., Moffatt, M.F., Daniels, S.E. et al. A Genetic Map of Chromosome 11 q, Including the Atopy Locus. Eur J Hum Genet 3, 188–194 (1995). https://doi.org/10.1159/000472294
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DOI: https://doi.org/10.1159/000472294
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