Abstract
We have localized several markers in the Xq24–25 region containing DXS12, DXS42 and DXS37 which are closely linked to the X-linked lymphoproliferative syndrome (XLP) locus. A 850-kb restriction map has been established by mapping overlapping YACs and showed that DXS12 and DXS42 are physically linked within about 50 kb. DXS37 is separated from these two loci at a maximum distance of 3,700 kb. Several new probes have been generated which will contribute to further physical mapping of this region.
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Acknowledgements
We thank Drs J. Skare, J.L. Mandel, B. White, H. Roper, G. Sutherland, K. Paulson and P.N. Goodfellow for kindly providing the probes and cell lines. We thank Drs M. Ross, S. Meier-Ewert and H. Lehrach for high-density filters of the ICRF YAC library and G. Zehetner and C. Douglas for YAC clone acquisition through the ICRF reference library database. We thank Dr. J. Feunteun for helpful suggestions, Drs R. Montesano and I. Oberlé for their critical reading of the manuscript and Dr. J. Cheney for editing the manuscript. We also thank C. Bonnardel for material collection and A. Trochard for preparing the manuscript. Q.W. is a recipient of a grant from Comité Départemental de l’Ain, Ligue Nationale Française contre le Cancer.
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Wang, Q., Ishikawa-Brush, Y., Monaco, A.P. et al. Physical Mapping of Xq24–25 around Loci Closely Linked to the X-Linked Lymphoproliferative Syndrome Locus: An Overlapping YAC Map and Linkage between DXS12, DXS42, and DXS37. Eur J Hum Genet 1, 64–71 (1993). https://doi.org/10.1159/000472388
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DOI: https://doi.org/10.1159/000472388
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