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Electrical activity of the heart and angiotensin-converting enzyme inhibitors on the hyperpolarising action of enalapril

Journal of Human Hypertension volume 16, pages S89–S92 (2002)Cite this article

Abstract

This paper describes the effect of angiotensin- converting enzyme (ACE) inhibitors on the electrical properties of the heart, particularly the effect of these drugs on heart cell coupling and impulse propagation and the possible implications for the generation of malignant ventricular arrhythmias. The hyperpolarising action of enalapril is described and evidence is presented that the activation of the sodium-potassium pump is involved in the increment in membrane potential elicited by the ACE inhibitor.

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Acknowledgements

This work was supported by the American Heart Association, and the National Institutes of Health (HL-34148, and G12 RRO3051).

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  1. Department of Pharmacology, Medical Sciences Campus, UPR, San Juan, 00936, Puerto Rico, USA

    W C De Mello

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  1. W C De Mello
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Correspondence to W C De Mello.

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De Mello, W. Electrical activity of the heart and angiotensin-converting enzyme inhibitors on the hyperpolarising action of enalapril. J Hum Hypertens 16 (Suppl 1), S89–S92 (2002). https://doi.org/10.1038/sj.jhh.1001351

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