Figure 4

The effects of diazepam (1.25 mg/kg) and SH-053-S-CH3-2′F (10, 20 and 30 mg/kg, designated as S-CH3-2′F) on the (a) distance travelled on open arms, (b) percentage of entries in open arms and (c) percentage of time spent on open arms of the EPM. Number of animals per treatment (for SOL through SH-053-S-CH3-2′F 30 mg/kg) was 10. *p<0.05 compared to solvent (SOL) group.