Figure 5 | Neuropsychopharmacology

Figure 5

From: Are GABAA Receptors Containing α5 Subunits Contributing to the Sedative Properties of Benzodiazepine Site Agonists?

Figure 5The alternative text for this image may have been generated using AI.

The effects of diazepam (1.25 mg/kg), SH-053-S-CH3 (30 mg/kg), SH-053-S-CH3-2′F (30 mg/kg, designated as SH-053-S-2′F) and SH-053-R-CH3 (30 mg/kg) on distance travelled in the central (hatched bars) and peripheral (open bars) zone of the activity chamber during 45 min of recording (total activity corresponds to the height of the whole bar). *p<0.05 compared to solvent (SOL) group. Number of animals per treatment (Figures 5 and 6) for SOL through SH-053-S-CH3-2′F 30 mg/kg was 8, and 4 for SH-053-R-CH3.

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