Table 3 Affinity (KI) of Pindolol, Penbutolol and Tertatolol for 5-HT1A Receptors in the CA1 Region of the Hippocampus (CA1), and the Dorsal Raphe Nucleus (DRN), in Post-Mortem Human Brain

From: β-blocker Binding to Human 5-HT1A Receptors in vivo and in vitro: Implications for Antidepressant Therapy

 

Pindolol (nM)

Penbutolol (nM)

Tertatolol (nM)

 

CA1

DRN

CA1

DRN

CA1

DRN

Subject 1

18.6

6.5

15.6

16.9

22.8

18.7

Subject 2

13.0

8.0

11.8

9.7

11.2

21.1

Subject 3

13.7

11.7

10.9

13.2

26.7

20.5

Subject 4

12.1

9.2

10.0

7.8

12.2

32.9

Mean ± SD

14.4 ± 2.9

8.9 ± 2.2

12.1 ± 2.5

11.9 ± 4.0

18.2 ± 7.7

23.3 ± 6.5

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