Evidence of Restricted Rotation about the N—C Bond in 2: 6-Disubstituted Acetanilides

Abstract

THE failure¹ to effect optical resolution of substituted anilines having two large ortho groups has left unconfirmed the theoretical possibility of restricted rotation about the nitrogen-nuclear single bond in such compounds. That such steric effects are indeed present in suitably constituted molecules is now proved by a method entirely independent of optical activity.