Abstract
THE current view1,2 that there is no relationship between optical activity (configuration) and antiplasmodial action in the Cinchona series does not appear to be fully justified.
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References
Goodman and Gilman, "The Pharmacological Basis of Therapeutics" 905 (New York, 1943).
Buttle, Henry, Solomon, Trevan and Gibbs, Biochem. J., 32, 47 (1938).
See Henry, Solomon and Gibbs, J. Chem. Soc., 592 (1937), in conjunction with King and Palmer, J. Chem. Soc., 121, 2577 (1922).
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Thron and Dirscherl, Liebigs Ann., 521, 48 (1935).
Henry, Chem. and Ind., 55 T, 111 (1936).
Cushny, "Biological Relations of Optically Isomeric Substances" (Baltimore, 1926).
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NEEMAN, M. Configuration and Antiplasmodial Activity. Nature 154, 550 (1944). https://doi.org/10.1038/154550a0
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DOI: https://doi.org/10.1038/154550a0
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