Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Assay of the Biological Value of a Protein by its Effect on Liver Cytoplasm

Nature volume 157, page 628 (1946)Cite this article

Abstract

IT has previously been shown1 that the amount of cytoplasm present in the liver is dependent both on the quality and quantity of the protein of the diet. Liver cytoplasm may be determined either by estimating the sum of the protein, phospholipin and nucleic acid contents of the liver or by estimating the non-glycogen non-lipid liver solids. It was suggested at the time that the determination of liver cytoplasm by means of the non-glycogen non-lipid solids may lend itself to a simple and rapid assessment of the biological value of a protein. Since then, investigations have been in progress in this laboratory with the view of developing a suitable method. The most important results obtained from a large number of tests have already been reported2,3, and a detailed paper is being prepared for publication.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kosterlitz, H. W., Biochem. J., 38, Proc. XIV (1944); Nature, 154, 207 (1944).

    Google Scholar 

  2. Kosterlitz, H. W., and Campbell, Rosa, M., J. Physiol., 104, 16P (1945); Nutr. Absts. Rev., 15, 1 (1945–46).

    Google Scholar 

  3. Kosterlitz, H. W., unpublished memorandum and reports to the Protein Requirements Committee of the Medical Research Council (November 1944, May 1945, January 1946). Proc. Nutrition Soc. (October 20, 1945), in the press.

  4. Harrison, Helen C., and Long, C. N. H., J. Biol. Chem., 161, 545 (1945).

    CAS  PubMed  Google Scholar 

  5. Henry, K. M., and Kon, S. K., J. Soc. Chem. Ind., 64. 227 (1945).

    CAS  Google Scholar 

  6. Chick, H., Copping, A. M., and Slack, E. B., Lancet, 250, 196 (1946).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physiology Department, University of Aberdeen,

    H. W. KOSTERLITZ & ROSA M. CAMPBELL

Authors
  1. H. W. KOSTERLITZ
    View author publications

    Search author on:PubMed Google Scholar

  2. ROSA M. CAMPBELL
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KOSTERLITZ, H., CAMPBELL, R. Assay of the Biological Value of a Protein by its Effect on Liver Cytoplasm. Nature 157, 628 (1946). https://doi.org/10.1038/157628b0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/157628b0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing