Abstract
IT has been suggested by Slade1 that the physiological activity of y-hexachlorocyclohexane, the active constituent of the insecticide 'Gammexane', is due to its antagonism towards the essential metabolite i-inositol, which is considered to have the same spatial configuration. Kirkwood and Phillips2 have recently shown that for the Gebrüer Mayer strain of Saccharomyces cerevisiæ this is in fact the case, since the y-isomer has a marked inhibitory effect on the growth of the organism, and the inhibition is overcome by the addition of more i-inositol to the medium. The other three isomers of hexachlorocyclohexane are but slightly inhibitory, and excess i-inositol is without effect.
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References
Slade, Hurter Memorial Lecture, Chem. and Ind., 314 (1945).
Kirkwood and Phillips, J. biol. Chem., 163, 251 (1946).
Buston and Pramanik, Biochem. J., 25, 1656 (1931).
McIlwain, Brit. J. Exp. Path., 23, 95 (1942).
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BUSTON, H., JACOBS, S. & GOLDSTEIN, A. Cause of Physiological Activity of 'Gammexane'. Nature 158, 22 (1946). https://doi.org/10.1038/158022b0
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DOI: https://doi.org/10.1038/158022b0
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