Abstract
THE effect of low concentrations of monomeric glyceraldehyde in inhibiting lactic acid formation in tissues using glucose but not in those using glycogen has been the subject of much experimentation and discussion. Stickland1 used dialysed muscle extract, reinforced with yeast hexokinase, and studied both substrates with this system. 0.01–0.001 M glyceraldehyde caused 80–90 per cent inhibition with glucose but had little or no effect with glycogen. Stickland found (private communication) by special tests that glyceraldehyde was not inhibiting hexokinase in this system.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Stickland, L. H., Biochem. J., 35, 859 (1941).
Warburg, O., and Christian, W., Biochem. Z., 303, 40 (1939).
Caputto, R., and Dixon, M., Nature, 156, 630 (1945).
Mendel, B., Bauch, M., and Strelitz, F., Klin. Wochenschrift, 10, 118 (1931).
Rudney, H., Arch. Biochem., 23, 67 (1949).
Needham, J., and Lehmann, H., Biochem. J., 31, 1913 (1937).
Mendel, B., Strelitz, F., and Mundell, D., Nature, 141, 288 (1938).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NEEDHAM, D., SIMINOVITCH, L. & RAPKINE, S. Mechanism of Glyceraldehyde Inhibition of Glycolysis. Nature 165, 521 (1950). https://doi.org/10.1038/165521a0
Issue date:
DOI: https://doi.org/10.1038/165521a0
This article is cited by
-
Beyond Darwinism’s Eclipse: Functional Evolution, Biochemical Recapitulation and Spencerian Emergence in the 1920s and 1930s
Journal for General Philosophy of Science (2010)
