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Direct Oxidation of Glucose-6-Phosphate by Animal Tissues

Nature volume 166, page 33 (1950)Cite this article

Abstract

YEAST1–4 and red blood cells5 contain enzyme systems which require coenzyme II and are capable of oxidizing glucose-6-phosphate to 6-phosphogluconic acid. The oxidation can also proceed further1,3,6, and evidence has been presented that in yeast stepwise C1- and C2-oxidation and decarboxylation may proceed via a pentose phosphoric ester; this was considered to be D-ribose-5-phosphate rather than D-arabinose-5-phosphate, which, although it has the configuration of D-glucose, is not attacked by yeast enzymes6. Further support for this view has recently been provided by the chromatographic identification of 2-ketogluconate and D-ribose-5-phosphate among the oxidation products of 6-phosphogluconic acid7.

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Authors and Affiliations

  1. Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London, W.1

    F. DICKENS & GERTRUDE E. GLOCK

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  1. F. DICKENS
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  2. GERTRUDE E. GLOCK
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DICKENS, F., GLOCK, G. Direct Oxidation of Glucose-6-Phosphate by Animal Tissues. Nature 166, 33 (1950). https://doi.org/10.1038/166033a0

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