Abstract
THE identity of 2-deoxyribose as a carbohydrate constituent of thymus nucleic acid was demonstrated by Levene. Using acidic hydrolysis1 and enzymic methods2, it was possible to prove that 2-deoxyribose was combined with the purine residues in the nucleic acid, though the nature of the sugar combined with the pyrimidine moiety is still uncertain3.
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References
Levene, P. A., and Jacobs, W. A., J. Biol. Chem., 12, 411 (1912).
Levene, P. A., J. Biol. Chem., 48, 119 (1921).
Tipson, R. S., “Advances in Carbohydrate Chemistry”, 1, 222 (1945); J. Amer. Pharm. Assoc., 37, No. 2, 45 (sci. edit., 1948).
Stacey, M., Chong-fu Li and Overend, W. G., Nature, 163, 538 (1949).
Deriaz, R. E., Stacey, M., Teece, E. G., and Wiggins, L. F., J. Chem. Soc., 1879 (1949).
Dische, Z., Mikrochemie, 8, 4 (1930).
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KENT, P. Direct Isolation of D-Deoxyribose by Mercaptanolysis of Calf Thymus Deoxyribonucleic Acid. Nature 166, 442–443 (1950). https://doi.org/10.1038/166442b0
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DOI: https://doi.org/10.1038/166442b0


