Effects of Oxygen Carriers and Oxygen Tensions on Fluoroacetate Inhibition of Citrate Utilization

Abstract

AFTER comparing the action of fluoroacetate on the respiration and citrate utilization in pigeon breast muscle and nematode parasites, Massey and Rogers¹ reported that the poison had little action on the pigeon breast muscle. In these experiments, methylene blue, 0.0003–0.0005M, was present in the brei. Later experiments carried out to discover why the fluoroacetate affected the parasite tissue but not the pigeon breast muscle showed that the inhibition obtained was associated with the nature of the oxygen carriers present, and with the oxygen tension at which the experiments were carried out.