Abstract
COMPLEMENT fixation with animal viruses has long been known, and Hoyle1 by the use of the complement fixation reaction has demonstrated a soluble influenza virus antigen which appears in infected cells of the chick embryo prior to the time in the growth-cycle at which infective virus can be found. Up to the present time, so far as I am aware, complement-fixing antibody to the bacterial viruses has not been demonstrated, nor has there been sought in phage-infected cells material analogous to the soluble influenza antigen of Hoyle. However, a conversation with Sir Macfarlane Burnet prompted a search for such substances.
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References
Hoyle, L., Brit. J. Bxp. Path., 29, 390 (1948).
Doermann, A. H., Carnegie Institution of Washington Year Book, 47, 176 (1948).
Cohen, S. S., Bact. Rev., 13, 1 (1949).
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ROUNTREE, P. Complement Fixing Antigen in T5 coli Bacteriophage. Nature 168, 34–35 (1951). https://doi.org/10.1038/168034b0
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DOI: https://doi.org/10.1038/168034b0
