Abstract
IN the course of clinical trials of the antithyroxine compound, n-butyl 3 : 5-diiodo-4-hydroxybenzoate1, on patients with thyrotoxicosis, the nature of the substances excreted in the urine was investigated. Practically the whole of the urinary iodine (545 mgm. per diem) was accounted for by the presence of a mixture of 3 : 5-diiodo-4-hydroxy- and, somewhat surprisingly, 3 : 5-diiodo-4-methoxy-benzoic acids in approximately equal proportions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sheahan, M. M., Wilkinson, J. H., and Maclagan, N. F., Biochem. J., 48, 188 (1951).
Paal, C., and Mohr, L., Ber., 29, 2302 (1896).
Wheeler, H. L., and Liddle, L. M., Amer. Chem. J., 42, 441 (1910).
Lederer, E., J. Chem. Soc., 2120 (1949).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MACLAGAN, N., WILKINSON, J. Methylation of a Phenolic Hydroxyl Group in the Human Body. Nature 168, 251 (1951). https://doi.org/10.1038/168251a0
Issue date:
DOI: https://doi.org/10.1038/168251a0
This article is cited by
-
Zur Frage des Vorkommens von 3-Hydroxy-4-methoxymandelsäure beim normalen und gesteigerten Katecholaminstoffwechsel
Klinische Wochenschrift (1967)
-
Über den katalytischen Einfluß der Schilddrüsenhormone und verwandter Substanzen auf die Reduktion von Cer(IV)-Sulfat durch arsenige Säure
Microchimica Acta (1962)
-
Carcinogenic Activity and O-Alkylation
Nature (1958)
