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Origin of the Resistance of Leukæmic Cells to Folic Acid Antagonists

Nature volume 169, pages 628–629 (1952)Cite this article

Abstract

LEUKÆMIC cells of the mouse develop resistance to various analogues of folic acid1,2. The variant cells in certain cases depend upon the 4-amino-substituted folic antagonists for optimal growth3. The changes are found to be stable, irreversible and heritable4, and occur generally among many transplantable leukæmias5.

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Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland

    L. W. LAW

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  1. L. W. LAW
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LAW, L. Origin of the Resistance of Leukæmic Cells to Folic Acid Antagonists. Nature 169, 628–629 (1952). https://doi.org/10.1038/169628a0

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