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Pure red cell aplasia after allogeneic stem cell transplantation with reduced conditioning

Bone Marrow Transplantation volume 26, pages 911–915 (2000)Cite this article

Abstract

Conditioning regimens with reduced intensity are used increasingly for allogeneic stem cell transplantation in elderly or extensively pretreated patients. Two cases of pure red cell aplasia after fludarabine-based conditioning and during immunosuppression with cyclosporin are described. Both patients received AB0-mismatched stem cells and had anti-donor isoagglutinins. Red cell recovery occurred after extended immunosuppression when isoagglutinins had disappeared. Colony assays indicated serologic suppression of the erythrocyte lineage in one patient. Since reduced conditioning permits donor cell engraftment primarily by suppression of host T cells, antibody-mediated immunological complications may occur more frequently than after ‘classical’ conditioning. Bone Marrow Transplantation (2000) 26, 911–915.

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Acknowledgements

We thank Ingrid Matt for the thorough documentation of the patient’s data. Barbara Sauer deserves gratitude for her expert technical assistance. We are indebted to the residents and nursing staff of the transplantation ward Löhr of Freiburg University Medical Center.

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  1. Department of Hematology/Oncology, Freiburg University Medical Center, Freiburg, Germany

    H Veelken, R Wäsch, D Behringer, H Bertz & J Finke

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  1. H Veelken
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  2. R Wäsch
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  3. D Behringer
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  4. H Bertz
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  5. J Finke
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Veelken, H., Wäsch, R., Behringer, D. et al. Pure red cell aplasia after allogeneic stem cell transplantation with reduced conditioning. Bone Marrow Transplant 26, 911–915 (2000). https://doi.org/10.1038/sj.bmt.1702629

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