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Breast Cancer

Outcomes of high-dose chemotherapy and autologous stem cell transplant in isolated locally recurrent breast cancer: a multicenter evaluation

Bone Marrow Transplantation volume 26, pages 947–953 (2000)Cite this article

Abstract

To determine the outcomes of women with isolated loco-regional recurrence (LRR) of breast cancer treated with high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) following conventional therapy, we conducted a retrospective review of 58 patients from five institutions treated between 1990 and 1998. Forty-five patients (78%) had ⩾2 poor prognostic factors (PPF) (defined as disease-free interval preceding LRR ⩽2 years, hormone receptor negative/refractory disease, and incomplete resection). At median follow-up of 14.2 (0.5–72) months, 36 patients (62%) developed progressive disease. Disease progression usually occurred at local (27 patients) vs distant (nine patients) sites. Median time to disease progression following ASCT was 6.1 (1.3–31.4) months. At last follow-up, 23 patients (40%) had expired (all due to disease progression), and 13 (22%) were alive with, and 22 (38%) without progressive disease. By Kaplan–Meier analysis, the estimated median PFS and OS was 20.3 and 29.2 months, respectively. In a multivariate model, complete remission at time of HDCT and estrogen-receptor positive disease were predictive of significantly longer PFS and OS. The survival of this cohort was similar to previous reports of those treated with conventional therapy alone, and to those with distant metastases treated with HDCT. Frequent progression locally, suggests that strategies to improve local disease control are needed. Bone Marrow Transplantation (2000) 26, 947–953.

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Authors and Affiliations

  1. Division of Bone Marrow Transplantation and Stem Cell Biology, Washington University School of Medicine, St Louis, MO, USA

    R Vij, J DiPersio, R Brown, K Trinkaus, LT Goodnough, H Khoury & D Adkins

  2. Division of Hematology and Oncology, University of Rochester Med Center, Rochester, NY, USA

    C Abboud & J Ponnuri

  3. Division of Bone Marrow Transplantation, Georgetown University Medical Center, Washington, DC, USA

    KR Meehan

  4. Carolinas Med Center, Charlotte, NC, USA

    G Frenette

  5. Division of Hematology, University of Texas Health Sciences Center, San Antonio, TX, USA

    C Freytes

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Vij, R., DiPersio, J., Brown, R. et al. Outcomes of high-dose chemotherapy and autologous stem cell transplant in isolated locally recurrent breast cancer: a multicenter evaluation. Bone Marrow Transplant 26, 947–953 (2000). https://doi.org/10.1038/sj.bmt.1702657

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