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Progenitor Cell Mobilisation

Mobilization of peripheral blood stem cells with high-dose cyclophosphamide or the DHAP regimen plus G-CSF in non-Hodgkin's lymphoma

Bone Marrow Transplantation volume 29, pages 285–290 (2002)Cite this article

Abstract

Our study analyzes the mobilization of hematopoietic stem cells after two chemotherapeutic regimens in non-Hodgkin's lymphoma (NHL) patients. The study included 72 patients with NHL (42 follicular and 30 large cells). The mean age was 37 years (range 17–60). Sixty-four patients (88.9%) had stage III–IV disease. Forty-eight patients (66.7%) had bone marrow involvement. Systemic B symptoms were present in 42 patients (58.3%). Mobilization chemotherapy regimens were randomly assigned as DHAP in 38 patients (52.7%) or cyclophosphamide (CPM) (5 g/m2) in 34 (47.2%) and the results of 132 procedures were analyzed. At the time of PBSC mobilization, 46 patients (63.9%) were considered to be responsive (complete remission, partial remission or sensitive relapse) and 26 (36.1%) not responsive (refractory relapse or refractory to therapy). Pre-apheresis CD34+ blood cell count and number of previous chemotherapy treatments were used to predict the total number of CD34+ cells in the apheresis product. The mobilizing regimens (CPM or DHAP) were similar in achieving the threshold CD34+ cell yield, for optimal engraftment. Since DHAP was very effective as salvage treatment, we suggest using DHAP as a mobilizing regimen in patients with active residual lymphoma at the time of stem cell collection.

Bone Marrow Transplantation (2002) 29, 285–290. doi:10.1038/sj.bmt.1703364

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Authors and Affiliations

  1. Haematology, University of Bari, Medical School, Policlinico Bari, Italy

    V Pavone, F Gaudio, A Guarini, T Perrone, A Zonno, P Curci & V Liso

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  1. V Pavone
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  2. F Gaudio
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  3. A Guarini
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Pavone, V., Gaudio, F., Guarini, A. et al. Mobilization of peripheral blood stem cells with high-dose cyclophosphamide or the DHAP regimen plus G-CSF in non-Hodgkin's lymphoma. Bone Marrow Transplant 29, 285–290 (2002). https://doi.org/10.1038/sj.bmt.1703364

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