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Mycosis Fungoides

Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

Bone Marrow Transplantation volume 31, pages 663–666 (2003)Cite this article

Summary:

Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.

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Authors and Affiliations

  1. Department of Hematology, IRCCS Ospedale Maggiore, Milano, Italy

    D Soligo, A Ibatici, P Morandi, C Annaloro, L Robbiolo, A Della Volpe & G Lambertenghi Deliliers

  2. Department of Dermatology, IRCCS Ospedale Maggiore, Milano, Italy

    E Berti, L Venegoni & E Alessi

  3. Transplantation Immunology and Blood Transfusion Services, IRCCS Ospedale Maggiore, Milano, Italy

    E Longhi

  4. Institute of Infectious and Tropical Diseases, University of Milano, Milano, Italy

    M Corbellino

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  1. D Soligo
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  2. A Ibatici
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  3. E Berti
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Soligo, D., Ibatici, A., Berti, E. et al. Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. Bone Marrow Transplant 31, 663–666 (2003). https://doi.org/10.1038/sj.bmt.1703872

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  • DOI: https://doi.org/10.1038/sj.bmt.1703872

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