Summary:
A 7-year-old boy with acute lymphoblastic leukemia (ALL) in second remission received an allogeneic PBSCT from his HLA-matched sister. Acute grade II graft-versus-host disease (GVHD) resolved with corticosteroids. Chronic GVHD in the skin and oral mucosa at around day 60 responded to corticosteroids and cyclosporin A. At 6 months after the transplant, he developed hepatic dysfunction with elevated serum transaminases and gamma-globulin. Liver biopsy revealed chronic inflammation with lymphocytes and plasma cells in portal areas without destruction of bile ducts, suggesting autoimmune hepatitis. While rare, autoimmune hepatitis should be considered a potential long-term complication in patients with hepatic dysfunction in the late post-transplant phase.
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Ogose, T., Watanabe, T., Suzuya, H. et al. Autoimmune hepatitis following allogeneic PBSCT from an HLA-matched sibling. Bone Marrow Transplant 31, 829–832 (2003). https://doi.org/10.1038/sj.bmt.1703923
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DOI: https://doi.org/10.1038/sj.bmt.1703923
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