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Graft-versus-tumor effect in a patient with advanced neuroblastoma who received HLA haplo-identical bone marrow transplantation

Bone Marrow Transplantation volume 32, pages 103–106 (2003)Cite this article

Summary:

A 5-year-old boy received CD34-positive HLA haplo-identical bone marrow transplantation from his father as treatment for refractory advanced neuroblastoma. He had residual disease in the para-aortic lymph nodes and multiple bones after the transplant. However, all of his residual disease had disappeared completely 3 years later. He developed grade I acute graft-versus-host disease (GVHD) but had no symptoms of chronic GVHD or any other complications. This case demonstrates the possibility of a graft-versus-tumor effect against neuroblastoma by HLA-mismatched allogeneic hematopoietic stem cell transplantation.

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Authors and Affiliations

  1. Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    M Inoue, K Yumura-Yagi, N Sakata, M Yasui, T Okamura & K Kawa

  2. Department of Pediatrics, Nara Medical University, Nara, Japan

    T Nakano

  3. Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    A Yoneda

  4. Department of Radiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    M Nishikawa

  5. Department of Pathology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    M Nakayama

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  1. M Inoue
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  2. T Nakano
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  3. A Yoneda
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  4. M Nishikawa
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  5. M Nakayama
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  6. K Yumura-Yagi
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  8. M Yasui
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  9. T Okamura
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  10. K Kawa
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Inoue, M., Nakano, T., Yoneda, A. et al. Graft-versus-tumor effect in a patient with advanced neuroblastoma who received HLA haplo-identical bone marrow transplantation. Bone Marrow Transplant 32, 103–106 (2003). https://doi.org/10.1038/sj.bmt.1704070

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