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Artificial Production of Incomplete Influenza Virus

Abstract

DIFFERENT strains of influenza virus yield different proportions of incomplete particles on heavy infection of the allantois1; and members of the influenza group can be arranged in a gradient based on this property2. The phenomenon itself remains unexplained, as is, indeed, the mechanism of incomplete virus production. In an approach to this problem we searched for other characteristics which would vary in gradient fashion, and hoped to establish a correlation between some better-known viral functions and the change in infectivity.

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References

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FAZEKAS DE ST. GROTH, S., GRAHAM, D. Artificial Production of Incomplete Influenza Virus. Nature 173, 637–638 (1954). https://doi.org/10.1038/173637b0

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