Hormonal Depression due to Treatment of Animals with Chlorpromazine

Abstract

IN an earlier paper, we have shown that in human patients chlorpromazine impairs the hypothalamus and through it the anterior pituitary lobe¹. This depressing effect balances itself in accordance with the push–pull principle so far as the following tropins are concerned: follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone and thyroid-stimulating hormone, since they produce secondary hormones. This is impossible, however, with regard to luteotropic hormone and somatotrophic hormone, as neither of them produces peripheral secondary hormones.