Abstract
COAGULASE production is a property of all pathogenic Staphylococci and is the most commonly accepted single criterion of pathogenicity. In addition it has been shown that coagulase plays a part in staphylococcal infections. Evidence for this is indirect: first, clottable plasma inhibits phagocytosis of Staphylococci1; secondly, rabbits can be protected from Staph. aureus infection by human coagulase-inhibiting serum2, and, also, they receive a degree of immunity against such infection by active immunization with coagulase3.
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References
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Boake, W. C., J. Immunol., 76, 89 (1956).
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SMITH, D., JOHNSTONE, J. Coagulase Activity in vivo. Nature 178, 982–983 (1956). https://doi.org/10.1038/178982a0
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DOI: https://doi.org/10.1038/178982a0
