Abstract
IT is generally accepted that histamine plays an important part in anaphylactic shock. In recent years, attention has been directed to 5-hydroxytryptamine, since this substance, together with histamine, is liberated from the platelets by the antigen–antibody reaction1. Further, 5-hydroxytryptamine causes a shock syndrome in guinea pigs which is similar to that caused by anaphylaxis2. Although Herxheimer was unable to protect guinea pigs from anaphylactic shock using lysergic acid diethylamide, a potent and specific antagonist of 5-hydroxytryptamine, Pallotta and Ward3 have observed significant protection using intravenous doses of lysergic acid diethylamide.
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References
Humphrey and Jaques, J. Physiol., 128, 9 (1955).
Herxheimer, J. Physiol., 128, 435 (1955).
Pallotta and Ward, J. Pharmacol., 119, 174 (1957).
Fink, Proc. Soc. Exp. Biol., 92, 673 (1956).
Brocklehurst, Symposium on 5-Hydroxytryptamine, London, April 1–2, 1957.
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SANYAL, R., WEST, G. 5-Hydroxytryptamine and Anaphylactic Shock. Nature 180, 1417 (1957). https://doi.org/10.1038/1801417a0
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DOI: https://doi.org/10.1038/1801417a0
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