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Mast Cell and Histamine in Rat Anaphylaxis: the Effect of Haemophilus pertussis

Nature volume 182, pages 1021–1022 (1958)Cite this article

Abstract

IT is now well established that mice and rats can be rendered hypersensitive to anaphylaxis by inoculation with Haemophilus pertussis vaccine, phase I organisms1. Treatment with H. pertussis also decreases the resistance of mice and rats to several unrelated factors as well as to histamine1,2 and serotonin3. It is also well known that most of the tissue histamine is located in the mast cells4 and that in rats and mice these cells are also rich in serotonin5. The fact that anaphylaxis in the rat produces mast cell damage and release of histamine into plasma6 led us to investigate the behaviour of these cells in anaphylaxis of rats treated with H. pertussis.

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Author notes

  1. I. MOTA: Fellow of the Rockefeller Foundation

Authors and Affiliations

  1. The National Institute for Medical Research, The Ridgeway, Mill Hill, London, N.W.7.

    I. MOTA

  2. Department of Histology, Faculty of Medicine, University of S. Paulo, Brazil

    I. MOTA

Authors
  1. I. MOTA
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MOTA, I. Mast Cell and Histamine in Rat Anaphylaxis: the Effect of Haemophilus pertussis . Nature 182, 1021–1022 (1958). https://doi.org/10.1038/1821021a0

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